The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition

  • Authors:
    • Xiaofei Wang
    • Yan Zhang
    • Xiwen Zhang
    • Wenxia Tian
    • Wenli Feng
    • Tingmei Chen
  • View Affiliations

  • Published online on: December 14, 2011     https://doi.org/10.3892/ijo.2011.1298
  • Pages: 1189-1195
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Abstract

Curcumin, the active component of turmeric, has been shown to protect against carcinogenesis and prevent tumor development in cancer. In our study, we tested the efficacy of a synthetic curcumin analogue, known as hydrazinocurcumin (HC), in breast cancer cells. The results demonstrated that compared to curcumin, HC was more effective in inhibiting STAT3 phosphorylation and downregulation of an array of STAT3 downstream targets which contributed to suppression of cell proliferation, loss of colony formation, depression of cell migration and invasion as well as induction of cell apoptosis. It was concluded that HC is a potent agent in the inhibition of STAT3 with more favorable pharmacological activity than curcumin, and HC may have translational potential as an effective cancer therapeutic or preventive agent for human breast carcinoma.
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April 2012
Volume 40 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang X, Zhang Y, Zhang X, Tian W, Feng W and Chen T: The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. Int J Oncol 40: 1189-1195, 2012
APA
Wang, X., Zhang, Y., Zhang, X., Tian, W., Feng, W., & Chen, T. (2012). The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition. International Journal of Oncology, 40, 1189-1195. https://doi.org/10.3892/ijo.2011.1298
MLA
Wang, X., Zhang, Y., Zhang, X., Tian, W., Feng, W., Chen, T."The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition". International Journal of Oncology 40.4 (2012): 1189-1195.
Chicago
Wang, X., Zhang, Y., Zhang, X., Tian, W., Feng, W., Chen, T."The curcumin analogue hydrazinocurcumin exhibits potent suppressive activity on carcinogenicity of breast cancer cells via STAT3 inhibition". International Journal of Oncology 40, no. 4 (2012): 1189-1195. https://doi.org/10.3892/ijo.2011.1298