Open Access

Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)

  • Authors:
    • Kouji Banno
    • Iori Kisu
    • Megumi Yanokura
    • Kosuke Tsuji
    • Kenta Masuda
    • Arisa Ueki
    • Yusuke Kobayashi
    • Wataru Yamagami
    • Hiroyuki Nomura
    • Nobuyuki Susumu
    • Daisuke Aoki
  • View Affiliations

  • Published online on: February 21, 2012     https://doi.org/10.3892/ijo.2012.1384
  • Pages: 1755-1762
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Abstract

Progestin preparations are made of synthetic progesterone and have often been used for hormone therapy in gynecological patients with endometriosis or endometrial cancer. Hormone therapy using progestin is considered to be one of the effective means of treatment particularly when dealing with endometrial cancer (an estrogen-dependent tumor). Numerous reports have been published concerning its efficacy in advanced or recurrent cases of atypical endometrial hyperplasia or endometrial cancer. Dienogest has been developed as a fourth-generation progestin for hormone therapy for endometriosis that can be used with high safety for long periods of time. In Japan, dienogest has been recommended as a first-line drug for endometriosis-associated pain. However, its antitumor activity has also been attracting close attention following a report that this drug suppressed the proliferation in vitro of endometrial cancer-derived cell lines which failed to respond to other progestins such as medroxyprogesterine acetate (MPA). The mechanism for antitumor activity of dienogest is considered to differ from the mechanism for antitumor activity of conventional progestin preparations used for treatment of endometrial cancer. This drug is expected to be clinically applicable as a new drug for the treatment of endometrial cancer.

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June 2012
Volume 40 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Susumu N, Susumu N, et al: Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). Int J Oncol 40: 1755-1762, 2012
APA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A. ... Aoki, D. (2012). Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review). International Journal of Oncology, 40, 1755-1762. https://doi.org/10.3892/ijo.2012.1384
MLA
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40.6 (2012): 1755-1762.
Chicago
Banno, K., Kisu, I., Yanokura, M., Tsuji, K., Masuda, K., Ueki, A., Kobayashi, Y., Yamagami, W., Nomura, H., Susumu, N., Aoki, D."Progestin therapy for endometrial cancer: The potential of fourth-generation progestin (Review)". International Journal of Oncology 40, no. 6 (2012): 1755-1762. https://doi.org/10.3892/ijo.2012.1384