Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells

  • Authors:
    • Jinheng Wang
    • Junying Li
    • Yanmei Huang
    • Xiangfeng Song
    • Zhiguo Niu
    • Zhitao Gao
    • Hui Wang
  • View Affiliations

  • Published online on: November 6, 2012     https://doi.org/10.3892/ijo.2012.1685
  • Pages: 269-276
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Abstract

Human T cell leukemia virus type 1 (HTLV-1) Tax-induced persistent activation of the NF-κB pathway is perceived as the primary cause of adult T cell leukemia (ATL), an aggressive leukemia caused by HTLV-1. Although elevated oncoprotein Bcl-3 levels are found in many HTLV-1-infected T cell lines and ATL cells, the role of Bcl-3 in the malignant progression caused by HTLV-1 retrovirus remains poorly understood. We confirmed, in the present study, that the Tax-induced NF-κB activation involves the regulation of Bcl-3. Both knockdown and overexpression of Bcl-3 inhibit the Tax-induced NF-κB activation. Similarly, excessive Bcl-3 inhibits the NF-κB/DNA binding activity and significantly decreases Tax-induced p65 nuclear translocation. The present results demonstrate the pleiotropic roles of Bcl-3 in Tax-induced NF-κB activation and indicate that a balance in the aberrant Bcl-3 expression may be established to play an important role in the maintenance of proliferation and inhibition of apoptosis in HTLV-1-infected and ATL cells.
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January 2013
Volume 42 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Wang J, Li J, Huang Y, Song X, Niu Z, Gao Z and Wang H: Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells. Int J Oncol 42: 269-276, 2013
APA
Wang, J., Li, J., Huang, Y., Song, X., Niu, Z., Gao, Z., & Wang, H. (2013). Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells. International Journal of Oncology, 42, 269-276. https://doi.org/10.3892/ijo.2012.1685
MLA
Wang, J., Li, J., Huang, Y., Song, X., Niu, Z., Gao, Z., Wang, H."Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells". International Journal of Oncology 42.1 (2013): 269-276.
Chicago
Wang, J., Li, J., Huang, Y., Song, X., Niu, Z., Gao, Z., Wang, H."Bcl-3 suppresses Tax-induced NF-κB activation through p65 nuclear translocation blockage in HTLV-1-infected cells". International Journal of Oncology 42, no. 1 (2013): 269-276. https://doi.org/10.3892/ijo.2012.1685