Open Access

Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7

Erratum in: /ijo/44/5/1781

  • Authors:
    • Shujie Cheng
    • Isaac Eliaz
    • Junfang Lin
    • Daniel Sliva
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  • Published online on: April 16, 2013     https://doi.org/10.3892/ijo.2013.1902
  • Pages: 1869-1874
  • Copyright: © Cheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

Poria cocos is a medicinal mushroom that is widely used in traditional Asian medicine. Here, we show that a characterized mixture of triterpenes extracted from P. cocos (PTE) and three purified triterpenes: pachymic acid (PA), dehydropachymic acid (DPA) and polyporenic acid C (PPAC) suppress the proliferation of the human pancreatic cancer cell lines Panc-1, MiaPaca-2, AsPc-1 and BxPc-3. Moreover, the most effective compound, PA, only slightly affects the proliferation of HPDE-6 normal pancreatic duct epithelial cells. The anti-proliferative effects of PTE on BxPc-3 cells are mediated by the cell cycle arrest at G0/G1 phase. DNA microarray analysis demonstrated that PTE significantly downregulates the expression of KRAS and matrix metalloproteinase-7 (MMP-7) in BxPc-3 cells. In addition, PTE and PA suppress the invasive behavior of BxPc-3 cells. The inhibition of invasiveness by PTE and PA was associated with the reduction of MMP-7 at the protein level and the role of MMP-7 further confirmed by the gene silencing of MMP-7 which also suppressed the invasiveness of BxPc-3 cells. In conclusion, triterpenes from P. cocos demonstrate anticancer and anti-invasive effects on human pancreatic cancer cells and can be considered as new therapeutic agents in the treatment of pancreatic cancer.
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June 2013
Volume 42 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Cheng S, Eliaz I, Lin J and Sliva D: Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . Int J Oncol 42: 1869-1874, 2013
APA
Cheng, S., Eliaz, I., Lin, J., & Sliva, D. (2013). Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 . International Journal of Oncology, 42, 1869-1874. https://doi.org/10.3892/ijo.2013.1902
MLA
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42.6 (2013): 1869-1874.
Chicago
Cheng, S., Eliaz, I., Lin, J., Sliva, D."Triterpenes from Poria cocos suppress growth and invasiveness of pancreatic cancer cells through the downregulation of MMP-7 Erratum in /ijo/44/5/1781 ". International Journal of Oncology 42, no. 6 (2013): 1869-1874. https://doi.org/10.3892/ijo.2013.1902