Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling

  • Authors:
    • Xiaolong Wang
    • Ning Zhang
    • Qiang Huo
    • Mingjuan Sun
    • Shangge Lv
    • Qifeng Yang
  • View Affiliations

  • Published online on: May 20, 2013     https://doi.org/10.3892/ijo.2013.1947
  • Pages: 321-328
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Estrogen receptor α (ERα) has been reported to play a critical role in promoting the growth of breast tumor cells. In the present study, we explored the effect of Huaier extract on estrogen receptor α signaling in breast cancer cell lines. Our data demonstrated that Huaier extract effectively inhibited the proliferation of the MCF-7, T47D and ZR-75-1 human breast cancer cell lines. For the mechanism analysis, we demonstrated that Huaier extract significantly reduced the mRNA and protein levels of ERα in all three ERα-positive cell lines. The downregulation of ERα protein levels was correlated with activation of the proteasomes. We demonstrated that Huaier extract markedly decreased the expression of both ERα and its downstream genes, inhibited the estrogen-stimulated proliferation and reversed the estrogen-induced activation of the nuclear factor κB (NFκB) pathway. Our study provides evidence that Huaier extract is a novel estrogen receptor modulator and is a promising drug for the prevention and treatment of ERα-positive human breast cancers.
View Figures
View References

Related Articles

Journal Cover

July 2013
Volume 43 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Wang X, Zhang N, Huo Q, Sun M, Lv S and Yang Q: Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. Int J Oncol 43: 321-328, 2013
APA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., & Yang, Q. (2013). Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling. International Journal of Oncology, 43, 321-328. https://doi.org/10.3892/ijo.2013.1947
MLA
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43.1 (2013): 321-328.
Chicago
Wang, X., Zhang, N., Huo, Q., Sun, M., Lv, S., Yang, Q."Huaier aqueous extract suppresses human breast cancer cell proliferation through inhibition of estrogen receptor α signaling". International Journal of Oncology 43, no. 1 (2013): 321-328. https://doi.org/10.3892/ijo.2013.1947