Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway

  • Authors:
    • Xiaolei Li
    • Zhaoxu Yang
    • Wenjie Song
    • Liang Zhou
    • Qingjun Li
    • Kaishan Tao
    • Jingshi Zhou
    • Xing Wang
    • Zhigang Zheng
    • Nan You
    • Kefeng Dou
    • Haimin Li
  • View Affiliations

  • Published online on: June 26, 2013     https://doi.org/10.3892/ijo.2013.1992
  • Pages: 793-802
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Abstract

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and it carries a poor prognosis due to a high rate of recurrence or metastasis after surgery. Bmi-1 plays a significant role in the growth and metastasis of many solid tumours. However, the exact mechanisms underlying Bmi-1-mediated cell invasion and metastasis, especially in HCC, are not yet known. In the present study, we sought to evaluate the expression of Bmi-1 in HCC samples and its relationship with clinicopathological characteristics and prognostic value, we also investigated related mechanisms underlying Bmi-1-mediated cell invasion in HCC. Our results showed that Bmi-1 is upregulated in HCC tissues compared to matched non-cancer liver tissues; and its expression is positively associated with tumour size, metastasis, venous invasion and AJCC TNM stage, respectively; multivariate analysis showed that high expression of Bmi-1 was an independent prognostic factor for overall survival. In addition, the shRNA-mediated inhibition of Bmi-1 reduced the invasiveness of two HCC cell lines in vitro by upregulating phosphatase and the tensin homolog deleted on chromosome 10 (PTEN) expression, inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt signalling pathway and downregulating the expression and activities of matrix metalloproteinase (MMP)-2 and MMP-9 and vascular endothelial growth factor (VEGF). These data demonstrate that Bmi-1 plays a vital role in HCC invasion and that Bmi-1 is a potential therapeutic target for HCC.
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September 2013
Volume 43 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Li X, Yang Z, Song W, Zhou L, Li Q, Tao K, Zhou J, Wang X, Zheng Z, You N, You N, et al: Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway. Int J Oncol 43: 793-802, 2013
APA
Li, X., Yang, Z., Song, W., Zhou, L., Li, Q., Tao, K. ... Li, H. (2013). Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway. International Journal of Oncology, 43, 793-802. https://doi.org/10.3892/ijo.2013.1992
MLA
Li, X., Yang, Z., Song, W., Zhou, L., Li, Q., Tao, K., Zhou, J., Wang, X., Zheng, Z., You, N., Dou, K., Li, H."Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway". International Journal of Oncology 43.3 (2013): 793-802.
Chicago
Li, X., Yang, Z., Song, W., Zhou, L., Li, Q., Tao, K., Zhou, J., Wang, X., Zheng, Z., You, N., Dou, K., Li, H."Overexpression of Bmi-1 contributes to the invasion and metastasis of hepatocellular carcinoma by increasing the expression of matrix metalloproteinase (MMP)‑2, MMP-9 and vascular endothelial growth factor via the PTEN/PI3K/Akt pathway". International Journal of Oncology 43, no. 3 (2013): 793-802. https://doi.org/10.3892/ijo.2013.1992