From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells

  • Authors:
    • Tiancheng Liu
    • Desiree E. Mendes
    • Clifford E. Berkman
  • View Affiliations

  • Published online on: July 18, 2013     https://doi.org/10.3892/ijo.2013.2020
  • Pages: 1125-1130
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Elucidating the role of androgen deprivation in the transition from androgen-dependence to independence may enable the development of more specific therapeutic strategies against prostate cancer. Our previous in vitro model was employed to further assess the effects of continuous androgen‑deprivation on prostate cancer cells (LNCaP) with respect to both androgen receptor (AR) and c-Met expression. The results indicated that long-term androgen deprivation resulted in a signaling pathway switch from AR to c-Met in androgen-sensitive cells, which was confirmed by immunofluorescence imaging and western blot analysis. This signaling pathway switch may be predictive of a more aggressive disease state following androgen deprivation therapy.
View Figures
View References

Related Articles

Journal Cover

October 2013
Volume 43 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Liu T, Mendes DE and Berkman CE: From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. Int J Oncol 43: 1125-1130, 2013
APA
Liu, T., Mendes, D.E., & Berkman, C.E. (2013). From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells. International Journal of Oncology, 43, 1125-1130. https://doi.org/10.3892/ijo.2013.2020
MLA
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43.4 (2013): 1125-1130.
Chicago
Liu, T., Mendes, D. E., Berkman, C. E."From AR to c-Met: Androgen deprivation leads to a signaling pathway switch in prostate cancer cells". International Journal of Oncology 43, no. 4 (2013): 1125-1130. https://doi.org/10.3892/ijo.2013.2020