Open Access

GLI1 upregulates C-JUN through a specific 130-kDa isoform

  • Authors:
    • Lauren Amable
    • Elaine Gavin
    • Kenji Kudo
    • Erhong Meng
    • Rodney P. Rocconi
    • Lalita A. Shevde
    • Eddie Reed
  • View Affiliations

  • Published online on: December 20, 2013     https://doi.org/10.3892/ijo.2013.2222
  • Pages: 655-661
  • Copyright: © Amable et al. This is an open access article distributed under the terms of Creative Commons Attribution License [CC BY_NC 3.0].

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Abstract

The Hedgehog pathway is molecularly linked to increased resistance to cisplatin and increased repair of platinum-DNA damage, through C-JUN. GLI1, which has five known isoforms, is a positive transcriptional regulator in Hedgehog. Southwestern blot assay, EMSA and ChIP assays indicate that only one of five isoforms of GLI1 may be responsible for the Hedgehog link with C-JUN and thus, increased platinum-DNA adduct repair. Cancer tissues express this 130-kDa isoform at levels 6-fold higher than non-malignant tissues; and this isoform exists in abundance in six of seven ovarian cancer cell lines examined.
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2014-March
Volume 44 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Amable L, Gavin E, Kudo K, Meng E, Rocconi RP, Shevde LA and Reed E: GLI1 upregulates C-JUN through a specific 130-kDa isoform. Int J Oncol 44: 655-661, 2014
APA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R.P., Shevde, L.A., & Reed, E. (2014). GLI1 upregulates C-JUN through a specific 130-kDa isoform. International Journal of Oncology, 44, 655-661. https://doi.org/10.3892/ijo.2013.2222
MLA
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44.3 (2014): 655-661.
Chicago
Amable, L., Gavin, E., Kudo, K., Meng, E., Rocconi, R. P., Shevde, L. A., Reed, E."GLI1 upregulates C-JUN through a specific 130-kDa isoform". International Journal of Oncology 44, no. 3 (2014): 655-661. https://doi.org/10.3892/ijo.2013.2222