PTEN expression is involved in the invasive properties of HNSCC: A key protein to consider in locoregional recurrence

  • Authors:
    • Jihane Mriouah
    • Cédric Boura
    • Myriem Gargouri
    • François Plénat
    • Béatrice Faivre
  • View Affiliations

  • Published online on: December 19, 2013     https://doi.org/10.3892/ijo.2013.2219
  • Pages: 709-716
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Abstract

Specific phenotypic effects of PTEN in head and neck squamous cell carcinoma (HNSCC) remain poorly defined without a direct causal connection between the loss of PTEN function and the progression of cancer. Here, we describe a potential role for PTEN in cancer progression. Using an shRNA targeting PTEN in HNSCC cells, we show that the loss of PTEN expression is associated with a decrease of cell adhesion, a reduction in E-cadherin expression while cell migration is promoted. Together with the tissue organization and molecular markers expressed in tumors derived from shPTEN cells in vivo, this study indicates that HNSCC cells deficient in PTEN expression undergo an epithelial‑mesenchymal transition (EMT). Additionally, our results suggest that both the low levels of expression and subcellular localization of PTEN are involved in the EMT phenotype, and ultimately in possible locoregional reccurences. We hypothesize that the loss of PTEN expression as well as the subcellular localization could be of interest as a predictive marker of recurrence in HNSCC.
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2014-March
Volume 44 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mriouah J, Boura C, Gargouri M, Plénat F and Faivre B: PTEN expression is involved in the invasive properties of HNSCC: A key protein to consider in locoregional recurrence. Int J Oncol 44: 709-716, 2014
APA
Mriouah, J., Boura, C., Gargouri, M., Plénat, F., & Faivre, B. (2014). PTEN expression is involved in the invasive properties of HNSCC: A key protein to consider in locoregional recurrence. International Journal of Oncology, 44, 709-716. https://doi.org/10.3892/ijo.2013.2219
MLA
Mriouah, J., Boura, C., Gargouri, M., Plénat, F., Faivre, B."PTEN expression is involved in the invasive properties of HNSCC: A key protein to consider in locoregional recurrence". International Journal of Oncology 44.3 (2014): 709-716.
Chicago
Mriouah, J., Boura, C., Gargouri, M., Plénat, F., Faivre, B."PTEN expression is involved in the invasive properties of HNSCC: A key protein to consider in locoregional recurrence". International Journal of Oncology 44, no. 3 (2014): 709-716. https://doi.org/10.3892/ijo.2013.2219