The role of Src family kinases in growth and migration of glioma stem cells

  • Authors:
    • Xiaosi Han
    • Wenbin Zhang
    • Xiuhua Yang
    • Crystal G. Wheeler
    • Catherine P. Langford
    • Lu Wu
    • Natalia Filippova
    • Gregory K. Friedman
    • Qiang Ding
    • Hassan M. Fathallah-Shaykh
    • G. Yancey Gillespie
    • L. Burt Nabors
  • View Affiliations

  • Published online on: May 9, 2014     https://doi.org/10.3892/ijo.2014.2432
  • Pages: 302-310
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Abstract

Src family kinases (SFKs) are highly expressed and active in clinical glioblastoma multiforme (GBM) specimens. SFKs inhibitors have been demonstrated to inhibit prolifer­ation and migration of glioma cells. However, the role of SFKs in glioma stem cells (GSCs), which are important for treatment resistance and recurrence, has not been reported. Here, we examined the expression pattern of individual members of SFKs and their functional role in CD133+ GSCs in comparison to primary glioma cells. We found that Fyn, c-Src and Yes were robustly expressed in GSCs while Lck was absent. Knockdown of c-Src, Yes or treatment with the SFK inhibitor dasatinib inhibited the migration of GSCs, but had no impact on their growth or self-renewal. These results suggest that SFKs represent an effective target for GSC migration but not for their growth.
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July-2014
Volume 45 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Han X, Zhang W, Yang X, Wheeler CG, Langford CP, Wu L, Filippova N, Friedman GK, Ding Q, Fathallah-Shaykh HM, Fathallah-Shaykh HM, et al: The role of Src family kinases in growth and migration of glioma stem cells. Int J Oncol 45: 302-310, 2014
APA
Han, X., Zhang, W., Yang, X., Wheeler, C.G., Langford, C.P., Wu, L. ... Nabors, L.B. (2014). The role of Src family kinases in growth and migration of glioma stem cells. International Journal of Oncology, 45, 302-310. https://doi.org/10.3892/ijo.2014.2432
MLA
Han, X., Zhang, W., Yang, X., Wheeler, C. G., Langford, C. P., Wu, L., Filippova, N., Friedman, G. K., Ding, Q., Fathallah-Shaykh, H. M., Gillespie, G. Y., Nabors, L. B."The role of Src family kinases in growth and migration of glioma stem cells". International Journal of Oncology 45.1 (2014): 302-310.
Chicago
Han, X., Zhang, W., Yang, X., Wheeler, C. G., Langford, C. P., Wu, L., Filippova, N., Friedman, G. K., Ding, Q., Fathallah-Shaykh, H. M., Gillespie, G. Y., Nabors, L. B."The role of Src family kinases in growth and migration of glioma stem cells". International Journal of Oncology 45, no. 1 (2014): 302-310. https://doi.org/10.3892/ijo.2014.2432