Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)

  • Authors:
    • Paul Toren
    • Amina Zoubeidi
  • View Affiliations

  • Published online on: August 14, 2014     https://doi.org/10.3892/ijo.2014.2601
  • Pages: 1793-1801
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Abstract

The PI3K/Akt pathway is an actively pursued therapeutic target in oncology. In prostate cancer, the activation of this pathway appears to be characteristic of many aggressive prostate cancers. Further, activation of the PI3K/Akt pathway is more frequently observed as prostate cancer progresses toward a resistant, metastatic disease. Signalling from this pathway activates numerous survival, growth, metabolic and metastatic functions characteristic of aggressive cancer. Biomarkers of this pathway have correlated activation of this pathway to high grade disease and higher risk of disease progression. Therefore there is significant interest in developing effective strategies to target this pathway in prostate cancer. In this review, we discuss the pre-clinical and clinical data relevant to targeting of the PI3K/Akt pathway in prostate cancer. In particular, we review the rationale and relevance of co-targeting approaches against the PI3K/Akt pathway. It is anticipated that through an improved understanding of the biology of the PI3K/Akt pathway in prostate cancer, relevant biomarkers and rationale combination therapies will optimize targeting of this pathway to improve outcomes among patients with aggressive prostate cancer.
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November-2014
Volume 45 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Toren P and Toren P: Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review). Int J Oncol 45: 1793-1801, 2014
APA
Toren, P., & Toren, P. (2014). Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review). International Journal of Oncology, 45, 1793-1801. https://doi.org/10.3892/ijo.2014.2601
MLA
Toren, P., Zoubeidi, A."Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)". International Journal of Oncology 45.5 (2014): 1793-1801.
Chicago
Toren, P., Zoubeidi, A."Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review)". International Journal of Oncology 45, no. 5 (2014): 1793-1801. https://doi.org/10.3892/ijo.2014.2601