Significance of AKT in gastric cancer (Review)

  • Authors:
    • Takamitsu Sasaki
    • Hiroki Kuniyasu
  • View Affiliations

  • Published online on: September 26, 2014     https://doi.org/10.3892/ijo.2014.2678
  • Pages: 2187-2192
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Abstract

AKT is a serine/threonine kinase activated downstream of integrin, which is a receptor for various pro‑proliferation and bioactive substances as well as the extracellular matrix receptor. The activation of AKT often contributes to tumorigenesis and plays a role in regulating cell motility, which is critical for local invasion and metastasis. In recent years, it has also drawn attention as a target of new molecular‑targeted agents. When analyzing the role of AKT in cancer cells, it is important to consider the microenvironment and variations of cancers. In this review, a basic overview of the role of AKT in normal and malignant tissues is provided, along with an in‑depth discussion of its role in gastric cancer and its potential as a target for therapy.
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December-2014
Volume 45 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Sasaki T and Sasaki T: Significance of AKT in gastric cancer (Review). Int J Oncol 45: 2187-2192, 2014
APA
Sasaki, T., & Sasaki, T. (2014). Significance of AKT in gastric cancer (Review). International Journal of Oncology, 45, 2187-2192. https://doi.org/10.3892/ijo.2014.2678
MLA
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45.6 (2014): 2187-2192.
Chicago
Sasaki, T., Kuniyasu, H."Significance of AKT in gastric cancer (Review)". International Journal of Oncology 45, no. 6 (2014): 2187-2192. https://doi.org/10.3892/ijo.2014.2678