SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity

  • Authors:
    • Soonduck Lee
    • Jinsun Kim
    • Samil Jung
    • Chengping Li
    • Young Yang
    • Keun Il Kim
    • Jong-Seok Lim
    • Yonghwan Kim
    • Choong-Il Cheon
    • Myeong-Sok Lee
  • View Affiliations

  • Published online on: January 13, 2015     https://doi.org/10.3892/ijo.2015.2840
  • Pages: 1377-1384
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Abstract

Vitamin C is considered as an important anticancer therapeutic agent although this view is debatable. In this study, we introduce a physiological mechanism demonstrating how vitamin C exerts anticancer activity that induces cell cycle arrest and apoptosis. Our previous and current data reveal that p53 tumor suppressor is the prerequisite factor for stronger anticancer effects of vitamin C. In addition, vitamin C-mediated cancer cell cytotoxicity appears to be achieved at least partly through the downregulation of the p34SEI-1 oncoprotein. Our previous study showed that p34SEI-1 increases the survival of various types of cancer cells by inhibiting their apoptosis. Present data suggest that vitamin C treatment decreases the p34SEI-1 expression at the protein level and therefore alleviates its anti-apoptotic activity. Of note, SIAH1, E3 ubiquitin ligase, appears to be responsible for the p34SEI-1 polyubiquitination and its subsequent degradation, which is dependent on p53. In summary, vitamin C increases cancer cell death by inducing SIAH1-mediated polyubiquitination/degradation of the p34SEI-1 oncoprotein in a p53-dependent manner.
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March-2015
Volume 46 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Lee S, Kim J, Jung S, Li C, Yang Y, Kim KI, Lim J, Kim Y, Cheon C, Lee M, Lee M, et al: SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity. Int J Oncol 46: 1377-1384, 2015
APA
Lee, S., Kim, J., Jung, S., Li, C., Yang, Y., Kim, K.I. ... Lee, M. (2015). SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity. International Journal of Oncology, 46, 1377-1384. https://doi.org/10.3892/ijo.2015.2840
MLA
Lee, S., Kim, J., Jung, S., Li, C., Yang, Y., Kim, K. I., Lim, J., Kim, Y., Cheon, C., Lee, M."SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity". International Journal of Oncology 46.3 (2015): 1377-1384.
Chicago
Lee, S., Kim, J., Jung, S., Li, C., Yang, Y., Kim, K. I., Lim, J., Kim, Y., Cheon, C., Lee, M."SIAH1-induced p34SEI-1 polyubiquitination/degradation mediates p53 preferential vitamin C cytotoxicity". International Journal of Oncology 46, no. 3 (2015): 1377-1384. https://doi.org/10.3892/ijo.2015.2840