Open Access

The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)

  • Authors:
    • Minsoo Cho
    • Insuk So
    • Jung Nyeo Chun
    • Ju-Hong Jeon
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  • Published online on: March 9, 2016     https://doi.org/10.3892/ijo.2016.3427
  • Pages: 1772-1782
  • Copyright: © Cho et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Geraniol is a dietary monoterpene alcohol that is found in the essential oils of aromatic plants. To date, experimental evidence supports the therapeutic or preventive effects of geraniol on different types of cancer, such as breast, lung, colon, prostate, pancreatic, and hepatic cancer, and has revealed the mechanistic basis for its pharmacological actions. In addition, geraniol sensitizes tumor cells to commonly used chemotherapy agents. Geraniol controls a variety of signaling molecules and pathways that represent tumor hallmarks; these actions of geraniol constrain the ability of tumor cells to acquire adaptive resistance against anticancer drugs. In the present review, we emphasize that geraniol is a promising compound or chemical moiety for the development of a safe and effective multi-targeted anticancer agent. We summarize the current knowledge of the effects of geraniol on target molecules and pathways in cancer cells. Our review provides novel insight into the challenges and perspectives with regard to geraniol research and to its application in future clinical investigation.
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May-2016
Volume 48 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Cho M, So I, Chun JN and Jeon J: The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review). Int J Oncol 48: 1772-1782, 2016
APA
Cho, M., So, I., Chun, J.N., & Jeon, J. (2016). The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review). International Journal of Oncology, 48, 1772-1782. https://doi.org/10.3892/ijo.2016.3427
MLA
Cho, M., So, I., Chun, J. N., Jeon, J."The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)". International Journal of Oncology 48.5 (2016): 1772-1782.
Chicago
Cho, M., So, I., Chun, J. N., Jeon, J."The antitumor effects of geraniol: Modulation of cancer hallmark pathways (Review)". International Journal of Oncology 48, no. 5 (2016): 1772-1782. https://doi.org/10.3892/ijo.2016.3427