5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways

  • Authors:
    • Jae-Kyung In
    • Jin-Kyu Kim
    • Joa Sub Oh
    • Dong-Wan Seo
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  • Published online on: March 10, 2016     https://doi.org/10.3892/ijo.2016.3436
  • Pages: 1907-1912
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Abstract

In the present study, we investigated the effects and molecular mechanism of 5-caffeoylquinic acid (5-CQA), a natural phenolic compound isolated from Ligularia fischeri, on cell invasion, proliferation and adhesion in p53 wild-type A549 and p53-deficient H1299 non-small cell lung cancer (NSCLC) cells. 5-CQA abrogated mitogen-stimulated invasion, but not proliferation, in both A549 and H1299 cells. In addition, 5-CQA inhibited mitogen-stimulated adhesion in A549 cells only. Anti-invasive activity of 5-CQA in A549 cells was mediated by the inactivation of p70S6K-dependent signaling pathway. In contrast, in H1299 cells the inactivation of Akt was found to be involved in 5-CQA-mediated inhibition of cell invasion. Collectively, these findings demonstrate the pharmacological roles and molecular targets of 5-CQA in regulating NSCLC cell fate, and suggest further evaluation and development of 5-CQA as a potential therapeutic agent for the treatment and prevention of lung cancer.
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May-2016
Volume 48 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
In J, Kim J, Oh JS and Seo D: 5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways. Int J Oncol 48: 1907-1912, 2016
APA
In, J., Kim, J., Oh, J.S., & Seo, D. (2016). 5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways. International Journal of Oncology, 48, 1907-1912. https://doi.org/10.3892/ijo.2016.3436
MLA
In, J., Kim, J., Oh, J. S., Seo, D."5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways". International Journal of Oncology 48.5 (2016): 1907-1912.
Chicago
In, J., Kim, J., Oh, J. S., Seo, D."5-Caffeoylquinic acid inhibits invasion of non-small cell lung cancer cells through the inactivation of p70S6K and Akt activity: Involvement of p53 in differential regulation of signaling pathways". International Journal of Oncology 48, no. 5 (2016): 1907-1912. https://doi.org/10.3892/ijo.2016.3436