Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy

  • Authors:
    • Xiaomin Yi
    • Jingfang Zhang
    • Fei Yan
    • Zifan Lu
    • Jiaoti Huang
    • Chongxian Pan
    • Jiarui Yuan
    • Wanxiang Zheng
    • Keke Zhang
    • Di Wei
    • Wei He
    • Jianlin Yuan
  • View Affiliations

  • Published online on: September 16, 2016     https://doi.org/10.3892/ijo.2016.3693
  • Pages: 1911-1920
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Abstract

Near-infrared fluorescence (NIRF) imaging is a novel imaging modality that allows for detection and real‑time monitoring of various pathophysiological states. IR-780 iodide has been used as an ideal platform to construct theranostic agents for cancer imaging and therapy. Abiraterone is a 17α‑hydroxylase/C17, 20‑lyase (CYP17) inhibitor that has been approved for use in patients with prostate cancer after androgen deprivation therapy. We report the synthesis and characterization of IR-780 conjugated abiraterone for the dual purpose of prostate cancer imaging and therapy. The new compound Abi-780 retained the excellent photophysical characteristics and NIRF imaging property of IR-780 dye. Abi-780 preferentially accumulated in plasmonic organelles of prostate cancer cells but not in normal prostate epithelial cells. Dose-dependent inhibition of cultured prostate cancer cells by Abi-780 was found. Abi-780 at 20 µM significantly reduced the capabilities of colony formation and migration/invasion potential as well as increasing the apoptosis rate of prostate cancer cells. NIRF imaging using Abi-780 selectively identified the tumors in mice bearing prostate cancer xenografts. Moreover, Abi-780 treatment significantly retarded the tumor growth. No severe systemic toxicity was observed in mice with daily injection of high-dose Abi-780 for one month. In conclusion, biocompatible Abi-780 is highly effective both in prostate cancer imaging and therapy. Constructing theranostic agents using the NIRF dye platform holds great promise in accurate diagnosis and targeted treatment of cancer.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Yi X, Zhang J, Yan F, Lu Z, Huang J, Pan C, Yuan J, Zheng W, Zhang K, Wei D, Wei D, et al: Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy. Int J Oncol 49: 1911-1920, 2016
APA
Yi, X., Zhang, J., Yan, F., Lu, Z., Huang, J., Pan, C. ... Yuan, J. (2016). Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy. International Journal of Oncology, 49, 1911-1920. https://doi.org/10.3892/ijo.2016.3693
MLA
Yi, X., Zhang, J., Yan, F., Lu, Z., Huang, J., Pan, C., Yuan, J., Zheng, W., Zhang, K., Wei, D., He, W., Yuan, J."Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy". International Journal of Oncology 49.5 (2016): 1911-1920.
Chicago
Yi, X., Zhang, J., Yan, F., Lu, Z., Huang, J., Pan, C., Yuan, J., Zheng, W., Zhang, K., Wei, D., He, W., Yuan, J."Synthesis of IR-780 dye-conjugated abiraterone for prostate cancer imaging and therapy". International Journal of Oncology 49, no. 5 (2016): 1911-1920. https://doi.org/10.3892/ijo.2016.3693