A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways

  • Authors:
    • Min-Hui Li
    • Ping Yang
    • Tai Yang
    • Kun Zhang
    • Yang Liu
    • Jin Liu
    • Li-Mei Li
    • Xing-Yan Luo
    • Shu-Xia Yang
    • Qiang Zou
    • Chong-Jie Zhang
  • View Affiliations

  • Published online on: September 6, 2016     https://doi.org/10.3892/ijo.2016.3684
  • Pages: 2127-2134
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Abstract

Benzothiazole derivatives are known for various biological activities, and their potency in cancer therapy have received considerable attention in recent years. However, the poor water solubility of most benzothiazole derivatives has limited their clinical application. We developed BD926, a novel water-soluble benzothiazole derivative and showed here that it could inhibit the proliferation and induce apoptosis of human Ramos B-lymphoma cells. We further showed that BD926 triggered apoptosis through both mitochondria and endoplasmic reticulum pathways. Moreover, BD926 caused cell cycle arrest at G0/G1 stage. Furthermore, accumulation of reactive oxygen species (ROS) were observed after BD926 treatment and ROS inhibitor was able to attenuate BD926-induced apoptosis, which suggested that BD926-induced apoptosis may be due to over-producing ROS. These results demonstrate the anticancer effects of BD926 in cell models and raise the possibility for the application of BD926 in cancer therapy.
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November-2016
Volume 49 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Li M, Yang P, Yang T, Zhang K, Liu Y, Liu J, Li L, Luo X, Yang S, Zou Q, Zou Q, et al: A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. Int J Oncol 49: 2127-2134, 2016
APA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J. ... Zhang, C. (2016). A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways. International Journal of Oncology, 49, 2127-2134. https://doi.org/10.3892/ijo.2016.3684
MLA
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49.5 (2016): 2127-2134.
Chicago
Li, M., Yang, P., Yang, T., Zhang, K., Liu, Y., Liu, J., Li, L., Luo, X., Yang, S., Zou, Q., Zhang, C."A novel water-soluble benzothiazole derivative BD926 triggers ROS-mediated B lymphoma cell apoptosis via mitochondrial and endoplasmic reticulum signaling pathways". International Journal of Oncology 49, no. 5 (2016): 2127-2134. https://doi.org/10.3892/ijo.2016.3684