Crosstalk between autophagy and intracellular radiation response (Review)

  • Authors:
    • Lelin Hu
    • Hao Wang
    • Li Huang
    • Yong Zhao
    • Junjie Wang
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  • Published online on: October 5, 2016     https://doi.org/10.3892/ijo.2016.3719
  • Pages: 2217-2226
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Abstract

Autophagy induced by radiation is critical to cell fate decision. Evidence now sheds light on the importance of autophagy induced by cancer radiotherapy. Traditional view considers radiation can directly or indirectly damage DNA which can activate DNA damage the repair signaling pathway, a large number of proteins participating in DNA damage repair signaling pathway such as p53, ATM, PARP1, FOXO3a, mTOR and SIRT1 involved in autophagy regulation. However, emerging recent evidence suggests radiation can also cause injury to extranuclear targets such as plasma membrane, mitochondria and endoplasmic reticulum (ER) and induce accumulation of ceramide, ROS, and Ca2+ concentration which activate many signaling pathways to modulate autophagy. Herein we review the role of autophagy in radiation therapy and the potent intracellular autophagic triggers induced by radiation. We aim to provide a more theoretical basis of radiation-induced autophagy, and provide novel targets for developing cytotoxic drugs to increase radiosensitivity.
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December-2016
Volume 49 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Hu L, Wang H, Huang L, Zhao Y and Wang J: Crosstalk between autophagy and intracellular radiation response (Review). Int J Oncol 49: 2217-2226, 2016
APA
Hu, L., Wang, H., Huang, L., Zhao, Y., & Wang, J. (2016). Crosstalk between autophagy and intracellular radiation response (Review). International Journal of Oncology, 49, 2217-2226. https://doi.org/10.3892/ijo.2016.3719
MLA
Hu, L., Wang, H., Huang, L., Zhao, Y., Wang, J."Crosstalk between autophagy and intracellular radiation response (Review)". International Journal of Oncology 49.6 (2016): 2217-2226.
Chicago
Hu, L., Wang, H., Huang, L., Zhao, Y., Wang, J."Crosstalk between autophagy and intracellular radiation response (Review)". International Journal of Oncology 49, no. 6 (2016): 2217-2226. https://doi.org/10.3892/ijo.2016.3719