FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER

  • Authors:
    • A RUSSO
    • V BAZAN
    • R CAMPANELLA
    • G DARDANONI
    • I CARRECA
    • S CUCCIARRE
    • A VECCHIONE
    • M PAVONEMACALUSO
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.633
  • Pages: 633-638
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Abstract

A series of 128 patients undergoing diagnostic and/or therapeutic transurethral resection for primary urothelial bladder carcinoma was prospectively studied in order to evaluate the relative importance of DNA-ploidy and S-phase fraction (SPF) by flow cytometry and of several clinicopathological features in predicting disease-free survival. Only frozen tissue was used. The mean follow-up was 22 months (range: 3-61 months). DNA-aneuploidy was present in 64% of the cases (82/128), while multiclonality was found in 29% of the DNA-aneuploid cases (24/82). In the univariate statistical analysis, high stage, DNA-aneuploidy (mono- and multiclonal patterns) and high SPF value (>11.6%) proved to be significantly related to the risk of intravesical recurrence, while a significant trend was present for histological grade. In the multivariate analysis only high SPF value (>11.6%) and DNA-aneuploidy were independently related to risk of relapse (RR of 2.39 and 2.40 respectively).

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
RUSSO A, BAZAN V, CAMPANELLA R, DARDANONI G, CARRECA I, CUCCIARRE S, VECCHIONE A and PAVONEMACALUSO M: FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER. Int J Oncol 5: 633-638, 1994
APA
RUSSO, A., BAZAN, V., CAMPANELLA, R., DARDANONI, G., CARRECA, I., CUCCIARRE, S. ... PAVONEMACALUSO, M. (1994). FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER. International Journal of Oncology, 5, 633-638. https://doi.org/10.3892/ijo.5.3.633
MLA
RUSSO, A., BAZAN, V., CAMPANELLA, R., DARDANONI, G., CARRECA, I., CUCCIARRE, S., VECCHIONE, A., PAVONEMACALUSO, M."FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER". International Journal of Oncology 5.3 (1994): 633-638.
Chicago
RUSSO, A., BAZAN, V., CAMPANELLA, R., DARDANONI, G., CARRECA, I., CUCCIARRE, S., VECCHIONE, A., PAVONEMACALUSO, M."FLOW CYTOMETRIC DNA ANALYSIS IN PREDICTION OF INTRAVESICAL RECURRENCE FROM HUMAN BLADDER-CANCER". International Journal of Oncology 5, no. 3 (1994): 633-638. https://doi.org/10.3892/ijo.5.3.633