REVERSIBLE PROLIFERATION ARREST OF RAT 3Y1 FIBROBLASTS AND SELECTIVE KILLING OF SIMIAN-VIRUS TRANSFORMED DERIVATION OF 3Y1 BY SHORT-CHAIN FATTY-ACIDS

  • Authors:
    • N MATSUO
    • K YAMADA
    • S NODA
    • K YAMASHITA
    • A OKUDA
    • G KIMURA
    • M SUGANO
  • View Affiliations

  • Published online on: September 1, 1994     https://doi.org/10.3892/ijo.5.3.655
  • Pages: 655-660
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Abstract

We examined the effect of saturated fatty acids with carbon number from 2 to 10 on proliferation and survival of rat untransformed fibroblast 3Y1 cells and its transformed derivation induced by Simian virus 40 (SV-3Y1). Acetic acid (C2) had no effect on proliferation of these cells. Among medium-chain fatty acids (C6-C10), caproic acid (C6) showed the lowest proliferation inhibitory effect. Caprylic (C8), pelargonic (C9), and capric acid (C10) exerted killing activity to both 3Y1 cells and SV-3Y1 cells, and the toxicity increased with the elongation of their alkyl chains. The toxicity was a little greater to 3Y1 cells than to SV-3Y1 cells. In contrast, short-chain fatty acids caused reversible proliferation arrest in 3Y1 cells at 25 mM in propionic (C3), 5 mM in butyric (C4) and 10 mM in valeric (C5) acids. These short-chain fatty acids arrested 3Y1 cells not only in the GI phase but also in the G2 phase of the cell cycle. To SV-3Y1 cells, however, these short-chain fatty acids were cytotoxic. The cytotoxicity to SV-3Y1 cells was the greatest in butyric acid among short-chain fatty acid tested. These results suggest that short-chain fatty acids exert ploliferation-arresting activity against normal cells while exerting killing activity to the transformed cells.

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September 1994
Volume 5 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MATSUO N, YAMADA K, NODA S, YAMASHITA K, OKUDA A, KIMURA G and SUGANO M: REVERSIBLE PROLIFERATION ARREST OF RAT 3Y1 FIBROBLASTS AND SELECTIVE KILLING OF SIMIAN-VIRUS TRANSFORMED DERIVATION OF 3Y1 BY SHORT-CHAIN FATTY-ACIDS. Int J Oncol 5: 655-660, 1994
APA
MATSUO, N., YAMADA, K., NODA, S., YAMASHITA, K., OKUDA, A., KIMURA, G., & SUGANO, M. (1994). REVERSIBLE PROLIFERATION ARREST OF RAT 3Y1 FIBROBLASTS AND SELECTIVE KILLING OF SIMIAN-VIRUS TRANSFORMED DERIVATION OF 3Y1 BY SHORT-CHAIN FATTY-ACIDS. International Journal of Oncology, 5, 655-660. https://doi.org/10.3892/ijo.5.3.655
MLA
MATSUO, N., YAMADA, K., NODA, S., YAMASHITA, K., OKUDA, A., KIMURA, G., SUGANO, M."REVERSIBLE PROLIFERATION ARREST OF RAT 3Y1 FIBROBLASTS AND SELECTIVE KILLING OF SIMIAN-VIRUS TRANSFORMED DERIVATION OF 3Y1 BY SHORT-CHAIN FATTY-ACIDS". International Journal of Oncology 5.3 (1994): 655-660.
Chicago
MATSUO, N., YAMADA, K., NODA, S., YAMASHITA, K., OKUDA, A., KIMURA, G., SUGANO, M."REVERSIBLE PROLIFERATION ARREST OF RAT 3Y1 FIBROBLASTS AND SELECTIVE KILLING OF SIMIAN-VIRUS TRANSFORMED DERIVATION OF 3Y1 BY SHORT-CHAIN FATTY-ACIDS". International Journal of Oncology 5, no. 3 (1994): 655-660. https://doi.org/10.3892/ijo.5.3.655