MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN HUMAN OVARIAN-CARCINOMA CELLS BY (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDIACARBOXYLATO)-PLATINUM (II) MONOHYDRATE AND MODULATION OF ITS SENSITIVITY BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE

  • Authors:
    • S ISONISHI
    • K OCHIAI
    • M YASUDA
    • K OHKAWA
    • Y TERASHIMA
  • View Affiliations

  • Published online on: December 1, 1994     https://doi.org/10.3892/ijo.5.6.1309
  • Pages: 1309-1314
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

DWA2114R, (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)-platinum( monohydrate, circumvented resistance in cisplatin (DDP)-resistant 2008/C13*5.25 cells to produce some collateral sensitivity. Intracellular platinum levels were not significantly different between parent 2008 and 2008/C13*5.25 cells after exposure to DWA2114R. At equimolar doses, platinum levels were 3.7 +/- 0.4 (SD)-fold (N=4; P<0.01) higher after exposure to DWA2114R than to DDP in 2008/C13*5.25 cells. This suggests that DWA2114R collateral sensitivity was due to its circumvention of impaired platinum accumulation in 2008/C13*5.25 cells, In contrast to our findings that 12-O-tetradecanoylphorbol- 13-acetate (TPA) induced cellular sensitivity to DDP and carboplatin in those cells, TPA did not alter the DWA2114R sensitivity in 2008 cells. Furthermore, it did reduce the DWA211R-resistance of 2008/C13*5.25 cells by a factor of 1.7 +/- 0.2 (SD)-fold (N=4; P<0.05) rather than increase sensitivity. This suggests that TPA sensitization effect was not common to any platinum compounds but was strongly related to their ligands.

Related Articles

Journal Cover

December 1994
Volume 5 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
ISONISHI S, OCHIAI K, YASUDA M, OHKAWA K and TERASHIMA Y: MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN HUMAN OVARIAN-CARCINOMA CELLS BY (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDIACARBOXYLATO)-PLATINUM (II) MONOHYDRATE AND MODULATION OF ITS SENSITIVITY BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE. Int J Oncol 5: 1309-1314, 1994
APA
ISONISHI, S., OCHIAI, K., YASUDA, M., OHKAWA, K., & TERASHIMA, Y. (1994). MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN HUMAN OVARIAN-CARCINOMA CELLS BY (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDIACARBOXYLATO)-PLATINUM (II) MONOHYDRATE AND MODULATION OF ITS SENSITIVITY BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE. International Journal of Oncology, 5, 1309-1314. https://doi.org/10.3892/ijo.5.6.1309
MLA
ISONISHI, S., OCHIAI, K., YASUDA, M., OHKAWA, K., TERASHIMA, Y."MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN HUMAN OVARIAN-CARCINOMA CELLS BY (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDIACARBOXYLATO)-PLATINUM (II) MONOHYDRATE AND MODULATION OF ITS SENSITIVITY BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE". International Journal of Oncology 5.6 (1994): 1309-1314.
Chicago
ISONISHI, S., OCHIAI, K., YASUDA, M., OHKAWA, K., TERASHIMA, Y."MECHANISM-RELATED CIRCUMVENTION OF CISPLATIN RESISTANCE IN HUMAN OVARIAN-CARCINOMA CELLS BY (-)-(R)-2-AMINOMETHYLPYRROLIDINE(1,1-CYCLOBUTANEDIACARBOXYLATO)-PLATINUM (II) MONOHYDRATE AND MODULATION OF ITS SENSITIVITY BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE". International Journal of Oncology 5, no. 6 (1994): 1309-1314. https://doi.org/10.3892/ijo.5.6.1309