PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells

  • Authors:
    • Amany Sayed Mawas
    • Vishwa Jeet Amatya
    • Rui Suzuki
    • Kei Kushitani
    • Mouchira M. Mohi El-Din
    • Yukio Takeshima
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  • Published online on: January 26, 2017     https://doi.org/10.3892/ijo.2017.3863
  • Pages: 1029-1034
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Abstract

Malignant mesothelioma is a major asbestos-related cancer with prolonged time lapse from the first exposure of asbestos to the development of mesothelioma. Most of mesothelioma patients show very poor prognosis, thus, an urgent improvement of its treatment is required by development of novel therapeutic strategies. RNA interference (RNAi) is a powerful tool in post-genomic research and cancer therapy through inhibition of gene expression. In the present study, we analyzed the function of PIM1 on mesothelioma cell lines with its knockdown by siRNA transfection. Here, we report that the downregulation of PIM1 led to suppression of cell proliferation by cell cycle arrest at G1 phase and suppression of cell invasion and migration. Considering the mesothelioma as rapidly growing invasive cancer, downregulation of PIM1 may have a potential role for therapeutic management of malignant mesothelioma.
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March-2017
Volume 50 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Mawas AS, Amatya VJ, Suzuki R, Kushitani K, Mohi El-Din MM and Takeshima Y: PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells. Int J Oncol 50: 1029-1034, 2017
APA
Mawas, A.S., Amatya, V.J., Suzuki, R., Kushitani, K., Mohi El-Din, M.M., & Takeshima, Y. (2017). PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells. International Journal of Oncology, 50, 1029-1034. https://doi.org/10.3892/ijo.2017.3863
MLA
Mawas, A. S., Amatya, V. J., Suzuki, R., Kushitani, K., Mohi El-Din, M. M., Takeshima, Y."PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells". International Journal of Oncology 50.3 (2017): 1029-1034.
Chicago
Mawas, A. S., Amatya, V. J., Suzuki, R., Kushitani, K., Mohi El-Din, M. M., Takeshima, Y."PIM1 knockdown inhibits cell proliferation and invasion of mesothelioma cells". International Journal of Oncology 50, no. 3 (2017): 1029-1034. https://doi.org/10.3892/ijo.2017.3863