Open Access

YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression

  • Authors:
    • Zhaoji Pan
    • Yiqing Tian
    • Bin Zhang
    • Xu Zhang
    • Hui Shi
    • Zhaofeng Liang
    • Peipei Wu
    • Rong Li
    • Benshuai You
    • Lunyu Yang
    • Fei Mao
    • Hui Qian
    • Wenrong Xu
  • View Affiliations

  • Published online on: August 23, 2017     https://doi.org/10.3892/ijo.2017.4101
  • Pages: 1055-1066
  • Copyright: © Pan et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Cancer-associated mesenchymal stem cells (MSCs) are critically involved in tumor development and progression. However, the mechanisms of action for MSCs in cancer remain largely unknown. Herein, we reported that the expression of Yes-associated protein 1 (YAP) was higher in gastric cancer derived mesenchymal stem cells (GC‑MSCs) than that in bone marrow derived MSCs (BM‑MSCs). YAP knockdown not only inhibited the growth, migration and invasion, and stemness of GC‑MSCs, but also suppressed their promoting effect on gastric cancer growth in vitro and in vivo. In addition, the interference of YAP expression in GC‑MSCs also attenuated the promoting role of gastric cancer cells in endothelial cell tube formation and migration. Mechanistically, YAP knockdown reduced the activation of β-catenin and its target genes in gastric cancer cells by GC‑MSCs. Taken together, these findings suggest that YAP activation in GC‑MSCs plays an important role in promoting gastric cancer progression, which may represent a potential target for gastric cancer therapy.
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October-2017
Volume 51 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Copy and paste a formatted citation
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Spandidos Publications style
Pan Z, Tian Y, Zhang B, Zhang X, Shi H, Liang Z, Wu P, Li R, You B, Yang L, Yang L, et al: YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression. Int J Oncol 51: 1055-1066, 2017
APA
Pan, Z., Tian, Y., Zhang, B., Zhang, X., Shi, H., Liang, Z. ... Xu, W. (2017). YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression. International Journal of Oncology, 51, 1055-1066. https://doi.org/10.3892/ijo.2017.4101
MLA
Pan, Z., Tian, Y., Zhang, B., Zhang, X., Shi, H., Liang, Z., Wu, P., Li, R., You, B., Yang, L., Mao, F., Qian, H., Xu, W."YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression". International Journal of Oncology 51.4 (2017): 1055-1066.
Chicago
Pan, Z., Tian, Y., Zhang, B., Zhang, X., Shi, H., Liang, Z., Wu, P., Li, R., You, B., Yang, L., Mao, F., Qian, H., Xu, W."YAP signaling in gastric cancer-derived mesenchymal stem cells is critical for its promoting role in cancer progression". International Journal of Oncology 51, no. 4 (2017): 1055-1066. https://doi.org/10.3892/ijo.2017.4101