Open Access

RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling

  • Authors:
    • Zi-Hao Qi
    • Hua-Xiang Xu
    • Shi-Rong Zhang
    • Jin-Zhi Xu
    • Shuo Li
    • He-Li Gao
    • Wei Jin
    • Wen-Quan Wang
    • Chun-Tao Wu
    • Quan-Xing Ni
    • Xian-Jun Yu
    • Liang Liu
  • View Affiliations

  • Published online on: February 7, 2018     https://doi.org/10.3892/ijo.2018.4269
  • Pages: 1105-1116
  • Copyright: © Qi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Pancreatic cancer is a lethal disease with a high metastatic potential. In our previous study, we identified a specific subgroup of patients with pancreatic cancer with a serum signature of carcinoembryonic antigen (CEA)+/cancer antigen (CA)125+/CA19-9 ≥1,000 U/ml. In this study, by using high-throughput screening analysis, we found that receptor-interacting protein kinases 4 (RIPK4) may be a key molecule involved in the high metastatic potential of this subgroup of patients with pancreatic cancer. A high RIPK4 expression predicted a poor prognosis and promoted pancreatic cancer cell migration and invasion via the RAF1/MEK/ERK pathway. Moreover, RIPK4 activated the RAF1/MEK/ERK pathway by regulating proteasome-mediated phosphatidylethanolamine binding protein 1 (PEBP1) degradation. The suppression of PEBP1 degradation eliminated the RIPK4-induced activation of RAF1/MEK/ERK signaling and pancreatic cancer cell migration or invasion. Thus, on the whole, the findings of this study indicated that RIPK4 was upregulated in the subgroup of pancreatic cancer with a high metastatic potential. RIPK4 overexpression promoted pancreatic cancer cell migration and invasion via the PEBP1 degradation-induced activation of the RAF1/MEK/ERK pathway.
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April-2018
Volume 52 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Qi Z, Xu H, Zhang S, Xu J, Li S, Gao H, Jin W, Wang W, Wu C, Ni Q, Ni Q, et al: RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. Int J Oncol 52: 1105-1116, 2018
APA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H. ... Liu, L. (2018). RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling. International Journal of Oncology, 52, 1105-1116. https://doi.org/10.3892/ijo.2018.4269
MLA
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling". International Journal of Oncology 52.4 (2018): 1105-1116.
Chicago
Qi, Z., Xu, H., Zhang, S., Xu, J., Li, S., Gao, H., Jin, W., Wang, W., Wu, C., Ni, Q., Yu, X., Liu, L."RIPK4/PEBP1 axis promotes pancreatic cancer cell migration and invasion by activating RAF1/MEK/ERK signaling". International Journal of Oncology 52, no. 4 (2018): 1105-1116. https://doi.org/10.3892/ijo.2018.4269