Open Access

MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1

  • Authors:
    • Feng Jiang
    • Qiuhua Yu
    • Ying Chu
    • Xiaobo Zhu
    • Wenbin Lu
    • Qian Liu
    • Qiang Wang
  • View Affiliations

  • Published online on: October 29, 2018     https://doi.org/10.3892/ijo.2018.4610
  • Pages: 128-138
  • Copyright: © Jiang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

MicroRNAs (miRNAs or miRs) have recently emerged as key regulators of various types of cancer, including non‑small cell lung cancer (NSCLC). The disrupted expression of miRNAs is associated with tumorigenesis and metastasis; however, the underlying mechanisms remain unclear. In this study, we demonstrate that miR‑98‑5p is downregulated in NSCLC and that miR‑98‑5p deficiency is associated with an advanced clinical stage and metastasis. A dual‑luciferase reporter assay was performed to confirm that transforming growth factor beta receptor 1 (TGFBR1), a key stimulator of tumor proliferation and metastasis, was a direct target of miR‑98‑5p. miR‑98‑5p overexpression resulted in the downregulation of TGFBR1 and the suppression of the viability, proliferation, migration and invasion of A549 and H1299 cells. Furthermore, miR‑98‑5p was demonstrated to be an efficient suppressor of tumor growth in an A549 subcutaneous xenograft tumor mouse model. Finally, miR‑98‑5p overexpression exerted a significant anti‑metastatic effect in a mouse model of pulmonary metastasis. On the whole, the results of the present study suggest that miR‑98‑5p/TGFBR1 may serve as promising targets for NSCLC therapy.
View Figures
View References

Related Articles

Journal Cover

January-2019
Volume 54 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Jiang F, Yu Q, Chu Y, Zhu X, Lu W, Liu Q and Wang Q: MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. Int J Oncol 54: 128-138, 2019
APA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., & Wang, Q. (2019). MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1. International Journal of Oncology, 54, 128-138. https://doi.org/10.3892/ijo.2018.4610
MLA
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54.1 (2019): 128-138.
Chicago
Jiang, F., Yu, Q., Chu, Y., Zhu, X., Lu, W., Liu, Q., Wang, Q."MicroRNA-98-5p inhibits proliferation and metastasis in non-small cell lung cancer by targeting TGFBR1". International Journal of Oncology 54, no. 1 (2019): 128-138. https://doi.org/10.3892/ijo.2018.4610