Open Access

Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells

  • Authors:
    • Panagiota Kasioumi
    • Paraskevi Vrazeli
    • Patra Vezyraki
    • Stelios Zerikiotis
    • Christos Katsouras
    • Alexander Damalas
    • Charalampos Angelidis
  • View Affiliations

  • Published online on: December 12, 2018     https://doi.org/10.3892/ijo.2018.4666
  • Pages: 821-832
  • Copyright: © Kasioumi et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Heat shock protein 70 (Hsp70; also known as HSP70A1A) is one of the most induced proteins in cancer cells; however, its role in cancer has not yet been fully elucidated. In the present study, we proposed a hypothetical model in which the silencing of Hsp70 enhanced the metastatic properties of the HeLa, A549 and MCF7 cancer cell lines. We consider that the inability of cells to form cadherin‑catenin complexes in the absence of Hsp70 stimulates their detachment from neighboring cells, which is the first step of anoikis and metastasis. Under these conditions, an epithelial‑to‑mesenchymal transition (EMT) pathway is activated that causes cancer cells to acquire a mesenchymal phenotype, which is known to possess a higher ability for migration. Therefore, we herein provide evidence of the dual role of Hsp70 which, according to international literature, first establishes a cancerous environment and then, as suggested by our team, regulates the steps of the metastatic process, including EMT and migration. Finally, the trigger for the anti‑metastatic properties that are acquired by cancer cells in the absence of Hsp70 appears to be the destruction of the Hsp70‑dependent heterocomplexes of E‑cadherin/catenins, which function like an anchor between neighboring cells.
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March-2019
Volume 54 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Kasioumi P, Vrazeli P, Vezyraki P, Zerikiotis S, Katsouras C, Damalas A and Angelidis C: Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells. Int J Oncol 54: 821-832, 2019
APA
Kasioumi, P., Vrazeli, P., Vezyraki, P., Zerikiotis, S., Katsouras, C., Damalas, A., & Angelidis, C. (2019). Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells. International Journal of Oncology, 54, 821-832. https://doi.org/10.3892/ijo.2018.4666
MLA
Kasioumi, P., Vrazeli, P., Vezyraki, P., Zerikiotis, S., Katsouras, C., Damalas, A., Angelidis, C."Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells". International Journal of Oncology 54.3 (2019): 821-832.
Chicago
Kasioumi, P., Vrazeli, P., Vezyraki, P., Zerikiotis, S., Katsouras, C., Damalas, A., Angelidis, C."Hsp70 (HSP70A1A) downregulation enhances the metastatic ability of cancer cells". International Journal of Oncology 54, no. 3 (2019): 821-832. https://doi.org/10.3892/ijo.2018.4666