Open Access

Human papillomavirus infection and ocular surface disease (Review)

  • Authors:
    • Aikaterini K. Chalkia
    • Georgios Bontzos
    • Demetrios A. Spandidos
    • Efstathios T. Detorakis
  • View Affiliations

  • Published online on: March 19, 2019     https://doi.org/10.3892/ijo.2019.4755
  • Pages: 1503-1510
  • Copyright: © Chalkia et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Human papillomavirus (HPV) infection has been implicated as a primary cause of lesions in the anogenital region, skin, oropharynx and respiratory tract. Additionally, the role of HPV in the pathogenesis of ocular surface disease has also been extensively studied. Conjunctival papilloma development has been strongly associated with the HPV infection of certain subtypes. On the other hand, the role of HPV in conjunctival pterygium, conjunctival intraepithelial neoplasia (CIN) and ocular surface squamous neoplasia (OSSN) remains controversial. Genetic predisposition and environmental factor is important in HPV hosts as regards the pathogenesis of ocular surface disease. Several studies have indicate a synergic role of HPV with ultraviolet radiation in pterygium establishment. A higher recurrence risk rate and more aggressive disease of ophthalmic pterygium is observed in cases of HPV infection. The purpose of this review was to provide a systematic review of the literature and to assist in a better understanding of the role of HPV in ocular surface disease.
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May-2019
Volume 54 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Chalkia AK, Bontzos G, Spandidos DA and Detorakis ET: Human papillomavirus infection and ocular surface disease (Review). Int J Oncol 54: 1503-1510, 2019
APA
Chalkia, A.K., Bontzos, G., Spandidos, D.A., & Detorakis, E.T. (2019). Human papillomavirus infection and ocular surface disease (Review). International Journal of Oncology, 54, 1503-1510. https://doi.org/10.3892/ijo.2019.4755
MLA
Chalkia, A. K., Bontzos, G., Spandidos, D. A., Detorakis, E. T."Human papillomavirus infection and ocular surface disease (Review)". International Journal of Oncology 54.5 (2019): 1503-1510.
Chicago
Chalkia, A. K., Bontzos, G., Spandidos, D. A., Detorakis, E. T."Human papillomavirus infection and ocular surface disease (Review)". International Journal of Oncology 54, no. 5 (2019): 1503-1510. https://doi.org/10.3892/ijo.2019.4755