RADIATION-INDUCED IRREVERSIBLE G(0) G(1) BLOCK IS ABOLISHED IN HUMAN-DIPLOID FIBROBLASTS TRANSFECTED WITH THE HUMAN PAPILLOMA-VIRUS E6 GENE - IMPLICATION OF THE P53-CIP1 WAF1 PATHWAY

  • Authors:
    • CY LI
    • H NAGASAWA
    • NM TSANG
    • JB LITTLE
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.233
  • Pages: 233-236
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Abstract

It has been shown previously with human diploid fibroblasts that a fraction of cells remains irreversibly blocked in the G(0)/G(1) phase of the cell cycle when the cells are irradiated in confluent, density-inhibited cultures and released by subculture to low density. In the present study we demonstrate that this G(0)/G(1) block is abolished when a human fibroblast cell strain is transfected with the human papilloma virus 16 E6 gene. Corresponding to the abolition of the G(0)/G(1) block in the E6-transfected cells, the expression of both the p53 and WAF1 genes is also abolished, suggesting that the p53 pathway of DNA damage response may be involved in this phenomenon.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
LI C, NAGASAWA H, TSANG N and LITTLE J: RADIATION-INDUCED IRREVERSIBLE G(0) G(1) BLOCK IS ABOLISHED IN HUMAN-DIPLOID FIBROBLASTS TRANSFECTED WITH THE HUMAN PAPILLOMA-VIRUS E6 GENE - IMPLICATION OF THE P53-CIP1 WAF1 PATHWAY. Int J Oncol 6: 233-236, 1995
APA
LI, C., NAGASAWA, H., TSANG, N., & LITTLE, J. (1995). RADIATION-INDUCED IRREVERSIBLE G(0) G(1) BLOCK IS ABOLISHED IN HUMAN-DIPLOID FIBROBLASTS TRANSFECTED WITH THE HUMAN PAPILLOMA-VIRUS E6 GENE - IMPLICATION OF THE P53-CIP1 WAF1 PATHWAY. International Journal of Oncology, 6, 233-236. https://doi.org/10.3892/ijo.6.1.233
MLA
LI, C., NAGASAWA, H., TSANG, N., LITTLE, J."RADIATION-INDUCED IRREVERSIBLE G(0) G(1) BLOCK IS ABOLISHED IN HUMAN-DIPLOID FIBROBLASTS TRANSFECTED WITH THE HUMAN PAPILLOMA-VIRUS E6 GENE - IMPLICATION OF THE P53-CIP1 WAF1 PATHWAY". International Journal of Oncology 6.1 (1995): 233-236.
Chicago
LI, C., NAGASAWA, H., TSANG, N., LITTLE, J."RADIATION-INDUCED IRREVERSIBLE G(0) G(1) BLOCK IS ABOLISHED IN HUMAN-DIPLOID FIBROBLASTS TRANSFECTED WITH THE HUMAN PAPILLOMA-VIRUS E6 GENE - IMPLICATION OF THE P53-CIP1 WAF1 PATHWAY". International Journal of Oncology 6, no. 1 (1995): 233-236. https://doi.org/10.3892/ijo.6.1.233