RESULTS OF A CLINICAL MULTICENTRIC RANDOMIZED PHASE-II STUDY OF NONSMALL CELL LUNG-CANCER TREATED WITH VINORELBINE CISPLATIN VERSUS VINORELBINE ALONE

  • Authors:
    • V LORUSSO
    • G PEZZELLA
    • AM CATINO
    • M GUIDA
    • S SCODITTI
    • R LORENZO
    • P TOMA
    • S DELLATOMMASA
    • M BISCONTI
    • A MASTRIA
    • E DURINI
    • F MUSCA
    • G SERRAVEZZA
    • S MAZZOTTA
    • RC FORCIGNANO
    • M DELENA
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.65
  • Pages: 65-68
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Abstract

From July 1992 to December 1993, 62 patients with non-small cell lung cancer (NSCLC) were admitted to a multicentric randomized study. The patients were treated with vinorelbine (V) alone at a dose of 25 mg/m(2)/i.v. weekly or with V at a dose of 25 mg/m(2)/i.v. on day 1 and 8 plus cisplatin at a dose of 80 mg/m(2)/i.v. on day 1 every 3-4 weeks (VP). An objective response was observed in 42% of patients treated with VP versus 12.5% of those treated with vinorelbine alone (p=0.038). There was no significant difference in the median survival duration between the two groups (38 versus 30 weeks for VP and V, respectively). Toxicity was tolerable but more severe in the VP regimen. These data suggest that V is an active agent in NSCLC and that the VP regimen may yield results comparable to other cisplatin combinations for treatment of these tumors.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
LORUSSO V, PEZZELLA G, CATINO A, GUIDA M, SCODITTI S, LORENZO R, TOMA P, DELLATOMMASA S, BISCONTI M, MASTRIA A, MASTRIA A, et al: RESULTS OF A CLINICAL MULTICENTRIC RANDOMIZED PHASE-II STUDY OF NONSMALL CELL LUNG-CANCER TREATED WITH VINORELBINE CISPLATIN VERSUS VINORELBINE ALONE. Int J Oncol 6: 65-68, 1995
APA
LORUSSO, V., PEZZELLA, G., CATINO, A., GUIDA, M., SCODITTI, S., LORENZO, R. ... DELENA, M. (1995). RESULTS OF A CLINICAL MULTICENTRIC RANDOMIZED PHASE-II STUDY OF NONSMALL CELL LUNG-CANCER TREATED WITH VINORELBINE CISPLATIN VERSUS VINORELBINE ALONE. International Journal of Oncology, 6, 65-68. https://doi.org/10.3892/ijo.6.1.65
MLA
LORUSSO, V., PEZZELLA, G., CATINO, A., GUIDA, M., SCODITTI, S., LORENZO, R., TOMA, P., DELLATOMMASA, S., BISCONTI, M., MASTRIA, A., DURINI, E., MUSCA, F., SERRAVEZZA, G., MAZZOTTA, S., FORCIGNANO, R., DELENA, M."RESULTS OF A CLINICAL MULTICENTRIC RANDOMIZED PHASE-II STUDY OF NONSMALL CELL LUNG-CANCER TREATED WITH VINORELBINE CISPLATIN VERSUS VINORELBINE ALONE". International Journal of Oncology 6.1 (1995): 65-68.
Chicago
LORUSSO, V., PEZZELLA, G., CATINO, A., GUIDA, M., SCODITTI, S., LORENZO, R., TOMA, P., DELLATOMMASA, S., BISCONTI, M., MASTRIA, A., DURINI, E., MUSCA, F., SERRAVEZZA, G., MAZZOTTA, S., FORCIGNANO, R., DELENA, M."RESULTS OF A CLINICAL MULTICENTRIC RANDOMIZED PHASE-II STUDY OF NONSMALL CELL LUNG-CANCER TREATED WITH VINORELBINE CISPLATIN VERSUS VINORELBINE ALONE". International Journal of Oncology 6, no. 1 (1995): 65-68. https://doi.org/10.3892/ijo.6.1.65