FISH ANALYSIS OF SUPERNUMERARY RING CHROMOSOME IN DERMATOFIBROSARCOMA PROTUBERANS

  • Authors:
    • G STENMAN
    • H ANDERSSON
    • JM MEISKINDBLOM
    • E ROIJER
    • LG KINDBLOM
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.81
  • Pages: 81-86
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Abstract

We describe the light- and electron microscopic, immunohistochemical, cell culture characteristics and cytogenetic findings of a case of dermatofibrosarcoma protuberans (DFSP). Cytogenetically, the lesion exhibited trisomy 8 and a supernumerary ring chromosome as the only clonal abnormalities found in about 35% of the cells analyzed. FISH-analysis of metaphase chromosomes revealed that the ring chromosome contained chromosome 17 sequences. Hybridization with a chromosome 17 centromere specific probe gave three signals in about 19% of the interphase nuclei suggesting that the ring also had a centromere derived from chromosome 17. These observations add to the evidence that supernumerary ring chromosomes, preferentially derived from chromosome 17, and trisomy 8 are non-random abnormalities in DFSP. Our findings also demonstrate the usefulness of FISH for identifying the origin of marker ring chromosomes.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
STENMAN G, ANDERSSON H, MEISKINDBLOM J, ROIJER E and KINDBLOM L: FISH ANALYSIS OF SUPERNUMERARY RING CHROMOSOME IN DERMATOFIBROSARCOMA PROTUBERANS. Int J Oncol 6: 81-86, 1995
APA
STENMAN, G., ANDERSSON, H., MEISKINDBLOM, J., ROIJER, E., & KINDBLOM, L. (1995). FISH ANALYSIS OF SUPERNUMERARY RING CHROMOSOME IN DERMATOFIBROSARCOMA PROTUBERANS. International Journal of Oncology, 6, 81-86. https://doi.org/10.3892/ijo.6.1.81
MLA
STENMAN, G., ANDERSSON, H., MEISKINDBLOM, J., ROIJER, E., KINDBLOM, L."FISH ANALYSIS OF SUPERNUMERARY RING CHROMOSOME IN DERMATOFIBROSARCOMA PROTUBERANS". International Journal of Oncology 6.1 (1995): 81-86.
Chicago
STENMAN, G., ANDERSSON, H., MEISKINDBLOM, J., ROIJER, E., KINDBLOM, L."FISH ANALYSIS OF SUPERNUMERARY RING CHROMOSOME IN DERMATOFIBROSARCOMA PROTUBERANS". International Journal of Oncology 6, no. 1 (1995): 81-86. https://doi.org/10.3892/ijo.6.1.81