EXPRESSION OF NSE AND PGP-9.5 IN NONSMALL-CELL LUNG-CANCERS

  • Authors:
    • C WALKER
    • HE BURNETT
    • WE KENYON
    • AV SPEDDING
  • View Affiliations

  • Published online on: January 1, 1995     https://doi.org/10.3892/ijo.6.1.99
  • Pages: 99-103
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Abstract

In NSCLC, neuron-specific; enolase (NSE) and protein-gene product 9.5 (PGP 9.5) were found in 12/14 squamous carcinomas, 1/1 large cell carcinomas and 2/10 adenocarcinomas in characteristic zonal patterns. PGP 9.5 was expressed predominantly in PCNA positive cells adjacent to blood vessels, while the greatest intensity of NSE stain was located in PCNA negative cells distant from vessels, in the centre of tumour masses. NSE expression was unrelated to the distribution of squamous cytokeratins 10 and 13. These studies suggest that expression of PGP 9.5 and NSE in NSCLC may be related to the proliferative or metabolic status of tumour cells.

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January 1995
Volume 6 Issue 1

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
WALKER C, BURNETT H, KENYON W and SPEDDING A: EXPRESSION OF NSE AND PGP-9.5 IN NONSMALL-CELL LUNG-CANCERS. Int J Oncol 6: 99-103, 1995
APA
WALKER, C., BURNETT, H., KENYON, W., & SPEDDING, A. (1995). EXPRESSION OF NSE AND PGP-9.5 IN NONSMALL-CELL LUNG-CANCERS. International Journal of Oncology, 6, 99-103. https://doi.org/10.3892/ijo.6.1.99
MLA
WALKER, C., BURNETT, H., KENYON, W., SPEDDING, A."EXPRESSION OF NSE AND PGP-9.5 IN NONSMALL-CELL LUNG-CANCERS". International Journal of Oncology 6.1 (1995): 99-103.
Chicago
WALKER, C., BURNETT, H., KENYON, W., SPEDDING, A."EXPRESSION OF NSE AND PGP-9.5 IN NONSMALL-CELL LUNG-CANCERS". International Journal of Oncology 6, no. 1 (1995): 99-103. https://doi.org/10.3892/ijo.6.1.99