EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER

  • Authors:
    • V SCHIRRMACHER
    • P BECKHOVE
    • A KRUGER
    • M ROCHA
    • V UMANSKY
    • KP FICHTNER
    • WE HULL
    • U ZANGEMEISTERWITTKE
    • A GRIESBACH
    • K JURIANZ
    • P VONHOEGEN
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.505
  • Pages: 505-521
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Abstract

A cellular cancer therapy is described with unique efficiency even in late-stage disease. in situ activated tumor-immune T cells, induced in allogeneic, tumor-resistant, MHC identical but superantigen different donor mice (B10.D2) could transfer strong graft-versus-leukemia (GvL) effects accompanied by only mild graft-versus-host (GvH) reactivity. Systemic immune cell transfer into 5 Gy irradiated DBA/2 mice bearing up to 4 week established syngeneic tumors and macrometastases led to massive infiltration of tumor tissues by CD4 and CD8 donor T lymphocytes. Upon interaction of immune CD4 donor T cells with host antigen presenting cells in synergy with immune CD8 donor T cells attacking the tumor cells directly, primary tumors (1.5 cm diameter) were encapsulated and rejected from the skin and liver metastases eradicated. For the first time, such adoptive cellular immunotherapy (ADI) was followed in individual live animals by P-31-NMR spectroscopy of primary tumors. An approximately 25,000 fold excess of metastatic tumor cells could be rejected as revealed quantitatively by FACScan analysis of lacZ gene transfected tumor cells.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
SCHIRRMACHER V, BECKHOVE P, KRUGER A, ROCHA M, UMANSKY V, FICHTNER K, HULL W, ZANGEMEISTERWITTKE U, GRIESBACH A, JURIANZ K, JURIANZ K, et al: EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. Int J Oncol 6: 505-521, 1995
APA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K. ... VONHOEGEN, P. (1995). EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER. International Journal of Oncology, 6, 505-521. https://doi.org/10.3892/ijo.6.3.505
MLA
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6.3 (1995): 505-521.
Chicago
SCHIRRMACHER, V., BECKHOVE, P., KRUGER, A., ROCHA, M., UMANSKY, V., FICHTNER, K., HULL, W., ZANGEMEISTERWITTKE, U., GRIESBACH, A., JURIANZ, K., VONHOEGEN, P."EFFECTIVE IMMUNE REJECTION OF ADVANCED METASTASIZED CANCER". International Journal of Oncology 6, no. 3 (1995): 505-521. https://doi.org/10.3892/ijo.6.3.505