ALLELIC STATUS ON 1P AND 11P15 IN NEUROBLASTOMA AND BENIGN GANGLIONEUROMA

  • Authors:
    • H KURAHASHI
    • T OUE
    • K AKAGI
    • M FUKUZAWA
    • A OKADA
    • A TAWA
    • S OKADA
    • I NISHISHO
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.669
  • Pages: 669-674
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Abstract

A tumor suppressor gene responsible for neuroblastoma (NB) is thought to be located on 1p, while a gene(s) commonly involved in embryonal tumors in childhood is(are) located on 11p15. To determine whether and how those putative genes affect tumorigenesis of NB, a total of 25 NBs and two benign ganglioneuromas (GNs) were examined by Southern technique with polymorphic markers on chromosomes 1 and 11 for analysis of the loss of heterozygosity at these loci. Because NB often features an increased number of chromosomes, we performed a detailed examination of allelic status and then compared it with their prognostic factors. While allelic loss on 1p was observed in only four cases (16%), eight additional cases showed allelic imbalance on a portion of 1p, indicating that these cases featured 1p deletions, so that the total number of cases with a 1p deletion was 12 out of 25 NBs (48%). A 1p deletion was observed not only in disseminated cases (8/14 of stage III or TV), but also in several cases with localized tumors (4/11 of stage I or II, p=0.529). Moreover, one GN case showed a 1p deletion. However, allelic loss or imbalance on 11p15 was observed in only two NBs (8%). These data suggest that 1p deletion is an initial event of NE tumorigenesis rather than a later event associated with tumor progression, while deletion of 11p15 is related to the development of a small proportion of NBs. Cases with 1p deletion do not always follow an aggressive clinical course and may differentiate into GN.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KURAHASHI H, OUE T, AKAGI K, FUKUZAWA M, OKADA A, TAWA A, OKADA S and NISHISHO I: ALLELIC STATUS ON 1P AND 11P15 IN NEUROBLASTOMA AND BENIGN GANGLIONEUROMA. Int J Oncol 6: 669-674, 1995
APA
KURAHASHI, H., OUE, T., AKAGI, K., FUKUZAWA, M., OKADA, A., TAWA, A. ... NISHISHO, I. (1995). ALLELIC STATUS ON 1P AND 11P15 IN NEUROBLASTOMA AND BENIGN GANGLIONEUROMA. International Journal of Oncology, 6, 669-674. https://doi.org/10.3892/ijo.6.3.669
MLA
KURAHASHI, H., OUE, T., AKAGI, K., FUKUZAWA, M., OKADA, A., TAWA, A., OKADA, S., NISHISHO, I."ALLELIC STATUS ON 1P AND 11P15 IN NEUROBLASTOMA AND BENIGN GANGLIONEUROMA". International Journal of Oncology 6.3 (1995): 669-674.
Chicago
KURAHASHI, H., OUE, T., AKAGI, K., FUKUZAWA, M., OKADA, A., TAWA, A., OKADA, S., NISHISHO, I."ALLELIC STATUS ON 1P AND 11P15 IN NEUROBLASTOMA AND BENIGN GANGLIONEUROMA". International Journal of Oncology 6, no. 3 (1995): 669-674. https://doi.org/10.3892/ijo.6.3.669