CHARACTERIZATION OF A NEW P53-MUTATED AND HPV-NEGATIVE HUMAN SQUAMOUS-CELL CERVICAL CARCINOMA-DERIVED CELL-LINE

  • Authors:
    • S FOGEL
    • JC AHOMADEGBE
    • ML LEBIHAN
    • M BARROIS
    • G RIOU
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.681
  • Pages: 681-686
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Abstract

A new cell line, designated IGR/Cut40, has been established from a stage II squamous cell carcinoma of the uterine cervix. These cells, which have a tetraploid DNA content and typical epithelial features, displayed a high proliferation rate and a powerful tumorigenic potential in immunodeficient mice. No human papillomavirus (HPV) DNA was detected using PCR and consensus primers. Sequencing of p53 cDNA revealed a mutation CGC(Arg)-->CAC(His) at codon 175 of the gene encoding for an abundant nuclear protein. IGR/Cut40 cell line should permit a better understanding of the HPV-infection-unrelated tumorigenesis of the uterine cervix.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
FOGEL S, AHOMADEGBE J, LEBIHAN M, BARROIS M and RIOU G: CHARACTERIZATION OF A NEW P53-MUTATED AND HPV-NEGATIVE HUMAN SQUAMOUS-CELL CERVICAL CARCINOMA-DERIVED CELL-LINE. Int J Oncol 6: 681-686, 1995
APA
FOGEL, S., AHOMADEGBE, J., LEBIHAN, M., BARROIS, M., & RIOU, G. (1995). CHARACTERIZATION OF A NEW P53-MUTATED AND HPV-NEGATIVE HUMAN SQUAMOUS-CELL CERVICAL CARCINOMA-DERIVED CELL-LINE. International Journal of Oncology, 6, 681-686. https://doi.org/10.3892/ijo.6.3.681
MLA
FOGEL, S., AHOMADEGBE, J., LEBIHAN, M., BARROIS, M., RIOU, G."CHARACTERIZATION OF A NEW P53-MUTATED AND HPV-NEGATIVE HUMAN SQUAMOUS-CELL CERVICAL CARCINOMA-DERIVED CELL-LINE". International Journal of Oncology 6.3 (1995): 681-686.
Chicago
FOGEL, S., AHOMADEGBE, J., LEBIHAN, M., BARROIS, M., RIOU, G."CHARACTERIZATION OF A NEW P53-MUTATED AND HPV-NEGATIVE HUMAN SQUAMOUS-CELL CERVICAL CARCINOMA-DERIVED CELL-LINE". International Journal of Oncology 6, no. 3 (1995): 681-686. https://doi.org/10.3892/ijo.6.3.681