BREAST-CARCINOMA CELL-LINES WITH METASTATIC POTENTIAL IN MICE

  • Authors:
    • RR MEHTA
    • JM GRAVES
    • A SHILKAITIS
    • GD HART
    • TK DASGUPTA
  • View Affiliations

  • Published online on: March 1, 1995     https://doi.org/10.3892/ijo.6.3.731
  • Pages: 731-736
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Abstract

We established and characterized three human breast carcinoma cell lines (two with metastatic potential) by in vivo-in vitro propagation of tumor tissues. Tissues were processed in culture as i) direct explants (n = 185); ii) cell suspensions obtained after enzymic digestion (n = 29); or iii) explants of xenografts established in vivo (n = 18). Tissues processed as explants or cell suspensions generated no viable cell lines. However, three cell lines (MAXF-401, MAXF-583 and OHSTMAM-4) were established from xenografts. All three showed characteristic features of human breast tumor tissue. All were tumorigenic in mice and MAXF-401 and MAXF-583 showed frequent distant metastasis following s.c. transplantation. All three overexpressed EGFR, p53 and c-erbB2 proteins.

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March 1995
Volume 6 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
MEHTA R, GRAVES J, SHILKAITIS A, HART G and DASGUPTA T: BREAST-CARCINOMA CELL-LINES WITH METASTATIC POTENTIAL IN MICE. Int J Oncol 6: 731-736, 1995
APA
MEHTA, R., GRAVES, J., SHILKAITIS, A., HART, G., & DASGUPTA, T. (1995). BREAST-CARCINOMA CELL-LINES WITH METASTATIC POTENTIAL IN MICE. International Journal of Oncology, 6, 731-736. https://doi.org/10.3892/ijo.6.3.731
MLA
MEHTA, R., GRAVES, J., SHILKAITIS, A., HART, G., DASGUPTA, T."BREAST-CARCINOMA CELL-LINES WITH METASTATIC POTENTIAL IN MICE". International Journal of Oncology 6.3 (1995): 731-736.
Chicago
MEHTA, R., GRAVES, J., SHILKAITIS, A., HART, G., DASGUPTA, T."BREAST-CARCINOMA CELL-LINES WITH METASTATIC POTENTIAL IN MICE". International Journal of Oncology 6, no. 3 (1995): 731-736. https://doi.org/10.3892/ijo.6.3.731