BENIGN AND MALIGNANT MYOEPITHELIOMA OF SALIVARY-GLAND - AN IMMUNOHISTOCHEMICAL EVALUATION

  • Authors:
    • Y TATEMOTO
    • K YONEDA
    • A OHNO
    • T OSAKI
  • View Affiliations

  • Published online on: June 1, 1995     https://doi.org/10.3892/ijo.6.6.1243
  • Pages: 1243-1248
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Abstract

Three myoepitheliomas (MEOs) derived from the salivary glands were examined immunohistochemically. Proliferating cell nuclear antigen (PCNA)-positive cells were very rare (less than 2% of all tumor cells) in localized tumors of case 1 (epithelioid) (E-oid) cells) and case 2 (plasmacytoid) (P-toid) cells with a small number of spindle-shaped cells), but the percentage of PCNA-positive cells was high (21.8%) in case 3 (clear cells) exhibiting bone destruction. Strong c-myc expression was detected in all the tumors, but p53 or c-erbB-2 protein was not detected in any of the cases. More than half of the clear cells were positive for epidermal growth factor (EGF), while fewer tumor cells in cases 1 and 2 expressed EGF. A few tumor cells in cases 2 and 3 were positive for EGF-receptor (R). Keratin was most prominent in the E-oid cells, The P-toid cells were most strongly positive for S-100 protein followed by the E-oid and clear cells. More than half of the spindle-shaped cells and one-third of the E-oid cells were positive for alpha-smooth muscle actin (alpha-SMA), but less than 5% of the clear cells and none of the P-toid cells were positive for alpha-SMA. These results suggest that tumor cells in MEO are heterogenous and have different proliferation activities.

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June 1995
Volume 6 Issue 6

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TATEMOTO Y, YONEDA K, OHNO A and OSAKI T: BENIGN AND MALIGNANT MYOEPITHELIOMA OF SALIVARY-GLAND - AN IMMUNOHISTOCHEMICAL EVALUATION. Int J Oncol 6: 1243-1248, 1995
APA
TATEMOTO, Y., YONEDA, K., OHNO, A., & OSAKI, T. (1995). BENIGN AND MALIGNANT MYOEPITHELIOMA OF SALIVARY-GLAND - AN IMMUNOHISTOCHEMICAL EVALUATION. International Journal of Oncology, 6, 1243-1248. https://doi.org/10.3892/ijo.6.6.1243
MLA
TATEMOTO, Y., YONEDA, K., OHNO, A., OSAKI, T."BENIGN AND MALIGNANT MYOEPITHELIOMA OF SALIVARY-GLAND - AN IMMUNOHISTOCHEMICAL EVALUATION". International Journal of Oncology 6.6 (1995): 1243-1248.
Chicago
TATEMOTO, Y., YONEDA, K., OHNO, A., OSAKI, T."BENIGN AND MALIGNANT MYOEPITHELIOMA OF SALIVARY-GLAND - AN IMMUNOHISTOCHEMICAL EVALUATION". International Journal of Oncology 6, no. 6 (1995): 1243-1248. https://doi.org/10.3892/ijo.6.6.1243