A REPORT ON THE COMPARATIVE RESPONSE OF SHEEP EPIDERMAL SQUAMOUS-CELL CARCINOMA TO INTRAARTERIAL VERSUS INTRAVENOUS CISPLATIN INFUSION

  • Authors:
    • GJS HARKER
    • FO STEPHENS
  • View Affiliations

  • Published online on: August 1, 1995     https://doi.org/10.3892/ijo.7.2.365
  • Pages: 365-370
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Abstract

There is an apparent lack of randomised clinical trials demonstrating a therapeutic advantage for intra-arterial, versus systemic, cisplatin administration as cancer treatment. A spontaneous, head and neck epidermal squamous cell carcinoma in sheep was used to compare intra-arterial and equivalent dose intravenous cisplatin infusion. The objective response rate for intra-arterially infused lesions was 73%, with a mean tumour regression for all carcinomas of 70% +/- 6 (sem). In comparison, 27% of intravenously treated carcinomas showed an objective response, the mean volume reduction being 42% +/- 6 (sem). Statistical comparison of the number of objective response lesions was significantly in favour of intra-arterial cisplatin therapy (p<0.05), as was the difference in the mean tumour response for both groups (p<0.005). The experimental data suggest that further study of the clinical application of intra-arterial induction cisplatin therapy is warranted.

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August 1995
Volume 7 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
HARKER G and HARKER G: A REPORT ON THE COMPARATIVE RESPONSE OF SHEEP EPIDERMAL SQUAMOUS-CELL CARCINOMA TO INTRAARTERIAL VERSUS INTRAVENOUS CISPLATIN INFUSION. Int J Oncol 7: 365-370, 1995
APA
HARKER, G., & HARKER, G. (1995). A REPORT ON THE COMPARATIVE RESPONSE OF SHEEP EPIDERMAL SQUAMOUS-CELL CARCINOMA TO INTRAARTERIAL VERSUS INTRAVENOUS CISPLATIN INFUSION. International Journal of Oncology, 7, 365-370. https://doi.org/10.3892/ijo.7.2.365
MLA
HARKER, G., STEPHENS, F."A REPORT ON THE COMPARATIVE RESPONSE OF SHEEP EPIDERMAL SQUAMOUS-CELL CARCINOMA TO INTRAARTERIAL VERSUS INTRAVENOUS CISPLATIN INFUSION". International Journal of Oncology 7.2 (1995): 365-370.
Chicago
HARKER, G., STEPHENS, F."A REPORT ON THE COMPARATIVE RESPONSE OF SHEEP EPIDERMAL SQUAMOUS-CELL CARCINOMA TO INTRAARTERIAL VERSUS INTRAVENOUS CISPLATIN INFUSION". International Journal of Oncology 7, no. 2 (1995): 365-370. https://doi.org/10.3892/ijo.7.2.365