MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW)

  • Authors:
    • H KIARIS
    • DA SPANDIDOS
  • View Affiliations

  • Published online on: September 1, 1995     https://doi.org/10.3892/ijo.7.3.413
  • Pages: 413-421
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Abstract

Ras family genes (H-, K- and N-ras) are implicated in a wide range of human rumours. Mutations are a major activating mechanism for the ras family genes, mainly in codons 12, 13 and 61, resulting in their conversion from proto-oncogenes to activated oncogenes. The detection of mutant ras alleles in human tumours has been performed by several investigators in a wide range of tissues. The aim of our review was to summarize the data obtained from these studies and to investigate whether the presence of mutant ras alleles was associated with particular clinical parameters.

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September 1995
Volume 7 Issue 3

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
KIARIS H and KIARIS H: MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW). Int J Oncol 7: 413-421, 1995
APA
KIARIS, H., & KIARIS, H. (1995). MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW). International Journal of Oncology, 7, 413-421. https://doi.org/10.3892/ijo.7.3.413
MLA
KIARIS, H., SPANDIDOS, D."MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW)". International Journal of Oncology 7.3 (1995): 413-421.
Chicago
KIARIS, H., SPANDIDOS, D."MUTATIONS OF RAS GENES IN HUMAN TUMORS (REVIEW)". International Journal of Oncology 7, no. 3 (1995): 413-421. https://doi.org/10.3892/ijo.7.3.413