DETECTION AND COMPARISON OF A 90-KD GLYCOPROTEIN TUMOR-ASSOCIATED ANTIGEN-SPECIFIC IMMUNE-COMPLEXES WITH CEA AND CA15-3 IN BREAST-CANCER

  • Authors:
    • RK GUPTA
    • DL MORTON
  • View Affiliations

  • Published online on: October 1, 1995     https://doi.org/10.3892/ijo.7.4.741
  • Pages: 741-747
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Abstract

Serum samples selected randomly from 106 patients that had histopathologically proven breast cancer, and from 107 self-proclaimed and apparently healthy females were analyzed for the presence of a 90 kD subunit containing glycoprotein TAA-specific immune complexes (IC) by a murine monoclonal antibody based ELISA. The incidence of the glycoprotein antigen specific IC in breast cancer patients was 63% (67/106), as indicated by the normalized ELISA value above 0.410 OD405nm. On the contrary, only 3 (2.8%) of 107 apparently healthy controls had positive ELISA value (p<0.05). Comparison of the glycoprotein TAA-specific IC results in breast cancer patients with evidence of disease with the results of CEA and CA15-3 revealed that the incidence of abnormal values was increased to 91%. Thus, use of the glycoprotein TAA specific-IC marker in conjunction with CEA and/or CA15-3 may prove to be more sensitive than when used alone for immunodiagnosis and immunoprognosis.

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October 1995
Volume 7 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
GUPTA R and GUPTA R: DETECTION AND COMPARISON OF A 90-KD GLYCOPROTEIN TUMOR-ASSOCIATED ANTIGEN-SPECIFIC IMMUNE-COMPLEXES WITH CEA AND CA15-3 IN BREAST-CANCER. Int J Oncol 7: 741-747, 1995
APA
GUPTA, R., & GUPTA, R. (1995). DETECTION AND COMPARISON OF A 90-KD GLYCOPROTEIN TUMOR-ASSOCIATED ANTIGEN-SPECIFIC IMMUNE-COMPLEXES WITH CEA AND CA15-3 IN BREAST-CANCER. International Journal of Oncology, 7, 741-747. https://doi.org/10.3892/ijo.7.4.741
MLA
GUPTA, R., MORTON, D."DETECTION AND COMPARISON OF A 90-KD GLYCOPROTEIN TUMOR-ASSOCIATED ANTIGEN-SPECIFIC IMMUNE-COMPLEXES WITH CEA AND CA15-3 IN BREAST-CANCER". International Journal of Oncology 7.4 (1995): 741-747.
Chicago
GUPTA, R., MORTON, D."DETECTION AND COMPARISON OF A 90-KD GLYCOPROTEIN TUMOR-ASSOCIATED ANTIGEN-SPECIFIC IMMUNE-COMPLEXES WITH CEA AND CA15-3 IN BREAST-CANCER". International Journal of Oncology 7, no. 4 (1995): 741-747. https://doi.org/10.3892/ijo.7.4.741