PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE-ACTIVITY AND BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER

  • Authors:
    • H TAKAHASHI
    • J UCHINO
    • M OGITA
    • F SASAKI
    • Y HATA
    • M YOSHIMOTO
    • Y AKASAKA
    • Y NAKANISHI
    • Y SAWADA
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1139
  • Pages: 1139-1144
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Abstract

We investigated whether Pyrimidine nucleoside phosphorylase (PyNPase) activity in breast cancer tissue correlated with biological characteristics of breast cancer. PyNPase activity, ER, PgR, EGFR, DNA ploidy pattern, PCNA positive cells and amplification of the c-erbB-2 gene were determined in specimens from 138 patients. PyNPase activity was significantly higher in ER negative than ER positive carcinomas (p<0.05), in PgR negative than PgR positive carcinomas (p<0.05) and significantly higher in tumors with c-erbB-2 gene amplification compared with tumors with no amplification (p<0.05). The results suggest that PyNPase activity in breast cancer tissue may be a new biological characteristic of breast cancer.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
TAKAHASHI H, UCHINO J, OGITA M, SASAKI F, HATA Y, YOSHIMOTO M, AKASAKA Y, NAKANISHI Y and SAWADA Y: PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE-ACTIVITY AND BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER. Int J Oncol 7: 1139-1144, 1995
APA
TAKAHASHI, H., UCHINO, J., OGITA, M., SASAKI, F., HATA, Y., YOSHIMOTO, M. ... SAWADA, Y. (1995). PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE-ACTIVITY AND BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER. International Journal of Oncology, 7, 1139-1144. https://doi.org/10.3892/ijo.7.5.1139
MLA
TAKAHASHI, H., UCHINO, J., OGITA, M., SASAKI, F., HATA, Y., YOSHIMOTO, M., AKASAKA, Y., NAKANISHI, Y., SAWADA, Y."PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE-ACTIVITY AND BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER". International Journal of Oncology 7.5 (1995): 1139-1144.
Chicago
TAKAHASHI, H., UCHINO, J., OGITA, M., SASAKI, F., HATA, Y., YOSHIMOTO, M., AKASAKA, Y., NAKANISHI, Y., SAWADA, Y."PYRIMIDINE NUCLEOSIDE PHOSPHORYLASE-ACTIVITY AND BIOLOGICAL CHARACTERISTICS OF BREAST-CANCER". International Journal of Oncology 7, no. 5 (1995): 1139-1144. https://doi.org/10.3892/ijo.7.5.1139