EXPRESSION AND STRUCTURE OF HOX GENES IN WILMS-TUMOR

  • Authors:
    • C CILLO
    • HP WILMORE
    • P BARBA
    • KW BROWN
  • View Affiliations

  • Published online on: November 1, 1995     https://doi.org/10.3892/ijo.7.5.1145
  • Pages: 1145-1150
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Abstract

We have investigated the expression of all 38 human HOX genes in Wilms' tumour (WT) tissue, and the structure of the HOXA cluster (at chromosome 7p15) in a WT patient who has a novel constitutional chromosome translocation (t(1;7)(q42;p15)). No rearrangement of the HOXA genes was found in the translocation patient, but between 26 and 28 HOX genes were expressed in WT tissue. Thus, although it appears unlikely that HOX genes are mutated in WT, their extensive expression in WT indicates that HOX genes may well be important factors in the aberrant differentiation which leads to Wilms' tumour.

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November 1995
Volume 7 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
CILLO C, WILMORE H, BARBA P and BROWN K: EXPRESSION AND STRUCTURE OF HOX GENES IN WILMS-TUMOR. Int J Oncol 7: 1145-1150, 1995
APA
CILLO, C., WILMORE, H., BARBA, P., & BROWN, K. (1995). EXPRESSION AND STRUCTURE OF HOX GENES IN WILMS-TUMOR. International Journal of Oncology, 7, 1145-1150. https://doi.org/10.3892/ijo.7.5.1145
MLA
CILLO, C., WILMORE, H., BARBA, P., BROWN, K."EXPRESSION AND STRUCTURE OF HOX GENES IN WILMS-TUMOR". International Journal of Oncology 7.5 (1995): 1145-1150.
Chicago
CILLO, C., WILMORE, H., BARBA, P., BROWN, K."EXPRESSION AND STRUCTURE OF HOX GENES IN WILMS-TUMOR". International Journal of Oncology 7, no. 5 (1995): 1145-1150. https://doi.org/10.3892/ijo.7.5.1145