Platinum-sensitive and platinum-resistant ovarian cancer tissues show differences in the relationships between mRNA levels of p53, ERCC1 and XPA

  • Authors:
    • J Yu
    • M Dabholkar
    • W Bennett
    • J Welsh
    • C Mu
    • F BostickBruton
    • E Reed
  • View Affiliations

  • Published online on: February 1, 1996     https://doi.org/10.3892/ijo.8.2.313
  • Pages: 313-317
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

We investigated the association between p53 mRNA expression and clinically relevant surrogates of nucleotide excision repair (ERCC1 and XPA) in 28 ovarian cancer specimens. We observed that platinum-resistant tumors showed higher mRNA levels of p53, ERCC1, and XPA than platinum-sensitive tumors; mRNA expression patterns in responders differed substantially from nonresponders; and p53 expression showed a strong correlation with the expression of ERCC1, and of XPA in platinum-sensitive tumor tissues, but not with platinum-resistant tumors. 47% of the mutations from p53 sequence analysis were not related to clinical response to chemotherapy. We conclude that the p53 influence on DNA repair in human malignancy may vary substantially from tumor to tumor, and that such differences are not necessarily related to the mutational status of p53.

Related Articles

Journal Cover

February 1996
Volume 8 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yu J, Dabholkar M, Bennett W, Welsh J, Mu C, BostickBruton F and Reed E: Platinum-sensitive and platinum-resistant ovarian cancer tissues show differences in the relationships between mRNA levels of p53, ERCC1 and XPA. Int J Oncol 8: 313-317, 1996
APA
Yu, J., Dabholkar, M., Bennett, W., Welsh, J., Mu, C., BostickBruton, F., & Reed, E. (1996). Platinum-sensitive and platinum-resistant ovarian cancer tissues show differences in the relationships between mRNA levels of p53, ERCC1 and XPA. International Journal of Oncology, 8, 313-317. https://doi.org/10.3892/ijo.8.2.313
MLA
Yu, J., Dabholkar, M., Bennett, W., Welsh, J., Mu, C., BostickBruton, F., Reed, E."Platinum-sensitive and platinum-resistant ovarian cancer tissues show differences in the relationships between mRNA levels of p53, ERCC1 and XPA". International Journal of Oncology 8.2 (1996): 313-317.
Chicago
Yu, J., Dabholkar, M., Bennett, W., Welsh, J., Mu, C., BostickBruton, F., Reed, E."Platinum-sensitive and platinum-resistant ovarian cancer tissues show differences in the relationships between mRNA levels of p53, ERCC1 and XPA". International Journal of Oncology 8, no. 2 (1996): 313-317. https://doi.org/10.3892/ijo.8.2.313