Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line

  • Authors:
    • M Hirata
    • M Itoh
    • A Tsuchida
    • H Ooishi
    • K Hanada
    • G Kajiyama
  • View Affiliations

  • Published online on: February 1, 1996     https://doi.org/10.3892/ijo.8.2.327
  • Pages: 327-330
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Abstract

Recent studies have shown that dexamethasone inhibits gelatinases. We investigated the effect of dexamethasone on the invasiveness of a human pancreatic cancer cell line. Tumor cells were treated with dexamethasone at various concentrations for 24 h. Cells were examined in an invasion assay. The expression and activity of MMP-9 in culture media were quantitated by Western blotting and gelatin zymogram. The invasiveness of cancer cells and expression of MMP-9 were decreased by dexamethasone in a dose-dependent manner. Dexamethasone may be a useful therapeutic agent in the treatment of pancreatic cancer.

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February 1996
Volume 8 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Hirata M, Itoh M, Tsuchida A, Ooishi H, Hanada K and Kajiyama G: Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line. Int J Oncol 8: 327-330, 1996
APA
Hirata, M., Itoh, M., Tsuchida, A., Ooishi, H., Hanada, K., & Kajiyama, G. (1996). Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line. International Journal of Oncology, 8, 327-330. https://doi.org/10.3892/ijo.8.2.327
MLA
Hirata, M., Itoh, M., Tsuchida, A., Ooishi, H., Hanada, K., Kajiyama, G."Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line". International Journal of Oncology 8.2 (1996): 327-330.
Chicago
Hirata, M., Itoh, M., Tsuchida, A., Ooishi, H., Hanada, K., Kajiyama, G."Dexamethasone inhibits invasiveness of a human pancreatic cancer cell line". International Journal of Oncology 8, no. 2 (1996): 327-330. https://doi.org/10.3892/ijo.8.2.327