Differential expression between PAX-6 and EN proteins in medulloblastoma

  • Authors:
    • S Vincent
    • N Turque
    • S Plaza
    • P Dhellemmes
    • J Hladky
    • R Assaker
    • M Ruchoux
    • S Saule
  • View Affiliations

  • Published online on: May 1, 1996     https://doi.org/10.3892/ijo.8.5.901
  • Pages: 901-910
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Abstract

A collection of 28 medulloblastomas was analyzed for expression of the developmental control genes PAX-6 and EN by immunohistochemical staining. Sixteen medulloblastomas expressed both EN and PAX-6 but, when differentiation could be assessed in the positive areas, PAX-6 is expressed in the less differentiated cells. Since Drosophila en encodes a negative regulator, we overexpressed the chicken en-1 in retinal pigmented epithelium cells. This resulted in Pax-6 down regulation. These results suggest a regulatory loop between PAX-6 and EN, two molecular markers of medulloblastoma.

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May 1996
Volume 8 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Vincent S, Turque N, Plaza S, Dhellemmes P, Hladky J, Assaker R, Ruchoux M and Saule S: Differential expression between PAX-6 and EN proteins in medulloblastoma. Int J Oncol 8: 901-910, 1996
APA
Vincent, S., Turque, N., Plaza, S., Dhellemmes, P., Hladky, J., Assaker, R. ... Saule, S. (1996). Differential expression between PAX-6 and EN proteins in medulloblastoma. International Journal of Oncology, 8, 901-910. https://doi.org/10.3892/ijo.8.5.901
MLA
Vincent, S., Turque, N., Plaza, S., Dhellemmes, P., Hladky, J., Assaker, R., Ruchoux, M., Saule, S."Differential expression between PAX-6 and EN proteins in medulloblastoma". International Journal of Oncology 8.5 (1996): 901-910.
Chicago
Vincent, S., Turque, N., Plaza, S., Dhellemmes, P., Hladky, J., Assaker, R., Ruchoux, M., Saule, S."Differential expression between PAX-6 and EN proteins in medulloblastoma". International Journal of Oncology 8, no. 5 (1996): 901-910. https://doi.org/10.3892/ijo.8.5.901