Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation

  • Authors:
    • H Miyazaki
    • H Shiku
    • K Furukawa
  • View Affiliations

  • Published online on: August 1, 1996     https://doi.org/10.3892/ijo.9.2.241
  • Pages: 241-245
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Abstract

A murine monoclonal antibody, S2-566, was generated by immunization with a melanoma line, SK-MEL-28. Although AbS2-566 showed a similar reaction pattern with that of anti-GD3 mAbR24 in cell surface serology, it recognized a disialyl galactosyl structure not only in GD3 but in GT1a and GQ1b. The suppression of the growth of cultured melanoma cells by AbS2-566 was not obvious, in contrast with AbR24. However, the mitogenic effects of AbS2-566 on peripheral lymphocytes were observed showing similar kinetics to those of mAbR24, suggesting different signaling effects based on the different epitope structures.

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August 1996
Volume 9 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Miyazaki H, Shiku H and Furukawa K: Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation. Int J Oncol 9: 241-245, 1996
APA
Miyazaki, H., Shiku, H., & Furukawa, K. (1996). Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation. International Journal of Oncology, 9, 241-245. https://doi.org/10.3892/ijo.9.2.241
MLA
Miyazaki, H., Shiku, H., Furukawa, K."Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation". International Journal of Oncology 9.2 (1996): 241-245.
Chicago
Miyazaki, H., Shiku, H., Furukawa, K."Differential effects of a murine monoclonal antibody reactive with the disialylgalactosyl residue on the growth of melanoma cells and T cell activation". International Journal of Oncology 9, no. 2 (1996): 241-245. https://doi.org/10.3892/ijo.9.2.241