Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer

  • Authors:
    • K Shibuta
    • M Mori
    • K Mimori
    • H Inoue
    • H Nakashima
    • K Baba
    • M Haraguchi
    • N Karimine
    • H Ueo
    • T Akiyoshi
  • View Affiliations

  • Published online on: August 1, 1996     https://doi.org/10.3892/ijo.9.2.247
  • Pages: 247-251
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Abstract

Prothymosin-alpha (PT-alpha) is a nuclear protein involved in cell proliferation. c-myc is implicated in the carcinogenesis of many human cancers. PT-alpha gene transcription is reported to be regulated by the c-myc gene in vitro. However, little has been reported on the PT-alpha and c-myc mRNA expressions in gastric cancer. We semi-quantitatively determined the PT-alpha and c-myc mRNA expressions in 60 pairs of gastric cancer tissue (T) and corresponding normal tissue (N) using the reverse transcriptase-polymerase chain reaction method. The average of T/N ratio was 1.20 for PT-alpha and 1.30 for c-myc. Cases demonstrating a T/N ratio of more than 1.0 were seen in 33 (55%) and 30 (50%) cases for PT-alpha and c-myc, respectively. No significant correlation was observed between either of these two mRNA expressions and any of the examined clinicopathologic factors for gastric cancer. However, a significant correlation was seen between the expressions of both genes (p<0.0001). The findings support the hypothesis that, regarding human gastric cancer, the transcription of PT-alpha is considered to be under the control of c-myc gene, however, the value of these gene expressions do not reflect biological behavior.

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August 1996
Volume 9 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Shibuta K, Mori M, Mimori K, Inoue H, Nakashima H, Baba K, Haraguchi M, Karimine N, Ueo H, Akiyoshi T, Akiyoshi T, et al: Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer. Int J Oncol 9: 247-251, 1996
APA
Shibuta, K., Mori, M., Mimori, K., Inoue, H., Nakashima, H., Baba, K. ... Akiyoshi, T. (1996). Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer. International Journal of Oncology, 9, 247-251. https://doi.org/10.3892/ijo.9.2.247
MLA
Shibuta, K., Mori, M., Mimori, K., Inoue, H., Nakashima, H., Baba, K., Haraguchi, M., Karimine, N., Ueo, H., Akiyoshi, T."Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer". International Journal of Oncology 9.2 (1996): 247-251.
Chicago
Shibuta, K., Mori, M., Mimori, K., Inoue, H., Nakashima, H., Baba, K., Haraguchi, M., Karimine, N., Ueo, H., Akiyoshi, T."Expression of prothymosin-alpha and c-myc mRNA in human gastric cancer". International Journal of Oncology 9, no. 2 (1996): 247-251. https://doi.org/10.3892/ijo.9.2.247