Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients

  • Authors:
    • J Hemmer
    • E Nagel
  • View Affiliations

  • Published online on: October 1, 1996     https://doi.org/10.3892/ijo.9.4.679
  • Pages: 679-683
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Pretherapeutic S-phase fractions of 68 carcinomas of the tongue and the floor of mouth were analysed by DNA flow cytometry immediately before intra-arterial induction chemotherapy with cisplatin and epirubicin or 5-fluorouracil. Patients with diploid tumors had an excellent 5-year survival rate of 89% in contrast to only 31% in the aneuploid group. Cell proliferation had no impact on the outcome of diploid cases. Node-positive patients with aneuploid tumors had a poor 18% 5-year survival rate, independent of S-phase fractions. Survival was significantly worse in nodenegative patients with high proliferating aneuploid tumors (45%) compared to the low-proliferative N-0 group (83%).

Related Articles

Journal Cover

October 1996
Volume 9 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Hemmer J and Hemmer J: Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients. Int J Oncol 9: 679-683, 1996
APA
Hemmer, J., & Hemmer, J. (1996). Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients. International Journal of Oncology, 9, 679-683. https://doi.org/10.3892/ijo.9.4.679
MLA
Hemmer, J., Nagel, E."Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients". International Journal of Oncology 9.4 (1996): 679-683.
Chicago
Hemmer, J., Nagel, E."Impact of tumor cell kinetics on the outcome of induction chemotherapy in oral carcinoma patients". International Journal of Oncology 9, no. 4 (1996): 679-683. https://doi.org/10.3892/ijo.9.4.679