Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases

  • Authors:
    • M Noda
    • M Kusunoki
    • H Yanagi
    • T Yamamura
    • J Utsunomiya
  • View Affiliations

  • Published online on: October 1, 1996     https://doi.org/10.3892/ijo.9.4.741
  • Pages: 741-746
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Abstract

We investigated whether carcinoembryonic antigen (CEA) could be used to predict the response and survival of patients treated with 5-FU. Between 1984 and 1994, 58 patients with unresectable hepatic metastases from colorectal carcinoma were enrolled in this study. Forty-three patients underwent resection of the primary colorectal malignancy, and a catheter was inserted into the hepatic artery during the operation (HAI group). Fifteen patients received no adjuvant therapy (non-HAI group). Patients with CEA values reduced by greater than or equal to 30% at 2 months after the start of 5-FU infusion had a significantly longer survival period than patients with a decrease of <30%. Terminal cases in CEA reduced by greater than or equal to 30% group revealed that CEA re-elevation was observed at 7 months, and the patients died 8 months later at 15 months. Our findings suggest that serum CEA monitoring is useful for predicting the survival time following 5-FU hepatic arterial infusion.

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October 1996
Volume 9 Issue 4

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Noda M, Kusunoki M, Yanagi H, Yamamura T and Utsunomiya J: Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases. Int J Oncol 9: 741-746, 1996
APA
Noda, M., Kusunoki, M., Yanagi, H., Yamamura, T., & Utsunomiya, J. (1996). Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases. International Journal of Oncology, 9, 741-746. https://doi.org/10.3892/ijo.9.4.741
MLA
Noda, M., Kusunoki, M., Yanagi, H., Yamamura, T., Utsunomiya, J."Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases". International Journal of Oncology 9.4 (1996): 741-746.
Chicago
Noda, M., Kusunoki, M., Yanagi, H., Yamamura, T., Utsunomiya, J."Serum carcinoembryonic antigen (CEA) correlates with the survival time during 5-FU hepatic arterial infusion chemotherapy for unresectable colorectal hepatic metastases". International Journal of Oncology 9, no. 4 (1996): 741-746. https://doi.org/10.3892/ijo.9.4.741