Glucosaminylmuramyldipeptide-induced changes in phenotype of melanoma cells result in their increased lysis by peripheral blood cells

  • Authors:
    • T Valyakina
    • A Malakhov
    • N Malakhova
    • E Petrova
    • S Bykovskaya
    • E Revazova
    • V Nesmeyanov
  • View Affiliations

  • Published online on: November 1, 1996     https://doi.org/10.3892/ijo.9.5.885
  • Pages: 885-891
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Abstract

Flow cytometry was used to show that biologically active N-acetylglucosamine-containing muramylpeptides (GMPs) induced in vitro dose-dependent increase in the expression of tumor-associated antigens (TAAs) characteristic for colon and mammary gland carcinomas, melanoma and lung adenocarcinoma. Forty to two hundred percent enhancement in TAA-expressing cells was observed after 18-48 h incubation with GMPs. In contrast, MHC class I antigen expression was not altered. Using MTT and chromium-release assays, melanoma cells treated in vitro with GMDP were shown to be more susceptible to killing by peripheral blood cells of healthy donors than non-treated cells. Fractionation of blood cells revealed that platelets were responsible for this effect.

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November 1996
Volume 9 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Valyakina T, Malakhov A, Malakhova N, Petrova E, Bykovskaya S, Revazova E and Nesmeyanov V: Glucosaminylmuramyldipeptide-induced changes in phenotype of melanoma cells result in their increased lysis by peripheral blood cells. Int J Oncol 9: 885-891, 1996
APA
Valyakina, T., Malakhov, A., Malakhova, N., Petrova, E., Bykovskaya, S., Revazova, E., & Nesmeyanov, V. (1996). Glucosaminylmuramyldipeptide-induced changes in phenotype of melanoma cells result in their increased lysis by peripheral blood cells. International Journal of Oncology, 9, 885-891. https://doi.org/10.3892/ijo.9.5.885
MLA
Valyakina, T., Malakhov, A., Malakhova, N., Petrova, E., Bykovskaya, S., Revazova, E., Nesmeyanov, V."Glucosaminylmuramyldipeptide-induced changes in phenotype of melanoma cells result in their increased lysis by peripheral blood cells". International Journal of Oncology 9.5 (1996): 885-891.
Chicago
Valyakina, T., Malakhov, A., Malakhova, N., Petrova, E., Bykovskaya, S., Revazova, E., Nesmeyanov, V."Glucosaminylmuramyldipeptide-induced changes in phenotype of melanoma cells result in their increased lysis by peripheral blood cells". International Journal of Oncology 9, no. 5 (1996): 885-891. https://doi.org/10.3892/ijo.9.5.885