Prognostic significance of multiple genetic lesions on chromosomes 19, 10, and 17 in oligodendrogliomas

  • Authors:
    • A Saxena
    • J Robertson
    • I Ali
    • J Schweitzer
  • View Affiliations

  • Published online on: November 1, 1996     https://doi.org/10.3892/ijo.9.5.901
  • Pages: 901-905
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Abstract

Patients diagnosed with oligodendrogliomas/oligoastrocytomas and with somatic loss of genes on chromosome 19q13.2-q13.3 survived for >5-6 years, a survival period typical of the tumors of oligodendroglial origin. One patient with oligoastrocytoma, harboring allelic loss on chromosome 10p in the tumor DNA, had a recurrence five years later with progression to anaplastic astrocytoma. However, another patient with oligoastrocytoma, whose tumor suffered multiple genetic lesions on chromosomes 19q13.2-13.3, 10q22-24, and 17p13.1 (a point mutation in the p53 gene), had two subsequent recurrences as anaplastic astrocytomas and a survival period of 29 months. Our data suggest that in tumors of oligodendroglial origin the inactivation of a tumor suppressor gene on chromosome 10, especially in conjunction with other genetic aberrations, is indicative of aggressive clinical course.

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November 1996
Volume 9 Issue 5

Print ISSN: 1019-6439
Online ISSN:1791-2423

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Spandidos Publications style
Saxena A, Robertson J, Ali I and Schweitzer J: Prognostic significance of multiple genetic lesions on chromosomes 19, 10, and 17 in oligodendrogliomas. Int J Oncol 9: 901-905, 1996
APA
Saxena, A., Robertson, J., Ali, I., & Schweitzer, J. (1996). Prognostic significance of multiple genetic lesions on chromosomes 19, 10, and 17 in oligodendrogliomas. International Journal of Oncology, 9, 901-905. https://doi.org/10.3892/ijo.9.5.901
MLA
Saxena, A., Robertson, J., Ali, I., Schweitzer, J."Prognostic significance of multiple genetic lesions on chromosomes 19, 10, and 17 in oligodendrogliomas". International Journal of Oncology 9.5 (1996): 901-905.
Chicago
Saxena, A., Robertson, J., Ali, I., Schweitzer, J."Prognostic significance of multiple genetic lesions on chromosomes 19, 10, and 17 in oligodendrogliomas". International Journal of Oncology 9, no. 5 (1996): 901-905. https://doi.org/10.3892/ijo.9.5.901